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Overview

Uniprot IDP84079
Protein NameADP-ribosylation factor 1
Gene NameArf1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
73 WDVGGQDKIRPLWRH

Function

Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (PubMed:23889934). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity)

Protein Sequence

10 MGNIFANLFK 20 GLFGKKEMRI 30 LMVGLDAAGK 40 TTILYKLKLG 50 EIVTTIPTIG 60 FNVETVEYKN 70 ISFTVWDVGG 80 QDKIRPLWRH 90 YFQNTQGLIF 100 VVDSNDRERV 110 NEAREELMRM 120 LAEDELRDAV 130 LLVFANKQDL 140 PNAMNAAEIT 150 DKLGLHSLRH 160 RNWYIQATCA 170 TSGDGLYEGL 180 DWLSNQLRNQ K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0030137 COPI-coated vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0012505 endomembrane system
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:1990583 phospholipase D activator activity
Molecular Function GO:0019904 protein domain specific binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0097061 dendritic spine organization
Biological Process GO:0055108 Golgi to transport vesicle transport
Biological Process GO:0006878 intracellular copper ion homeostasis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0060292 long-term synaptic depression
Biological Process GO:0097212 lysosomal membrane organization
Biological Process GO:1990386 mitotic cleavage furrow ingression
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0060999 positive regulation of dendritic spine development
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
Biological Process GO:1902824 positive regulation of late endosome to lysosome transport
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1902307 positive regulation of sodium ion transmembrane transport
Biological Process GO:0098974 postsynaptic actin cytoskeleton organization
Biological Process GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
Biological Process GO:1903725 regulation of phospholipid metabolic process
Biological Process GO:0002090 regulation of receptor internalization
Biological Process GO:0070142 synaptic vesicle budding
Biological Process GO:0034379 very-low-density lipoprotein particle assembly
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.