Search Results
Overview
| Uniprot ID | P84083 |
|---|---|
| Protein Name | ADP-ribosylation factor 5 |
| Gene Name | Arf5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 38 | TTILYKLKLGEIVTT |
Function
GTP-binding protein involved in protein trafficking. Contributes to vesicle budding and uncoating at the Golgi apparatus. Regulates mTORC1 activity at the plasma membrane by promoting its recruitment to membrane ruffles, facilitating activation via the PI3K/Akt signaling pathway. Acts as an early responder to lysosomal damage and participates in lysosomal quality control pathways
Protein Sequence
10
MGLTVSALFS
20
RIFGKKQMRI
30
LMVGLDAAGK
40
TTILYKLKLG
50
EIVTTIPTIG
60
FNVETVEYKN
70
ICFTVWDVGG
80
QDKIRPLWRH
90
YFQNTQGLIF
100
VVDSNDRERV
110
QESADELQKM
120
LQEDELRDAV
130
LLVFANKQDM
140
PNAMPVSELT
150
DKLGLQHLRS
160
RTWYVQATCA
170
TQGTGLYDGL
180
DWLSHELSKR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.