Search Results
Overview
| Uniprot ID | P84087 |
|---|---|
| Protein Name | Complexin-2 |
| Gene Name | Cplx2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | QALGGATKDMGKMLG |
| 18 | GATKDMGKMLGGEEE |
| 26 | MLGGEEEKDPDAQKK |
| 6 | **MDFVMKQALGGAT |
Function
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (PubMed:15870114)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0043303 | mast cell degranulation |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.