Overview
| Uniprot ID | P84244 |
|---|
| Protein Name | Histone H3.3 |
|---|
| Gene Name | H3-3a |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
PRKQLATKAARKSAP |
| 57 |
REIRRYQKSTELLIR |
| 80 |
REIAQDFKTDLRFQS |
Function
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MARTKQTARK
20
STGGKAPRKQ
30
LATKAARKSA
40
PSTGGVKKPH
50
RYRPGTVALR
60
EIRRYQKSTE
70
LLIRKLPFQR
80
LVREIAQDFK
90
TDLRFQSAAI
100
GALQEASEAY
110
LVGLFEDTNL
120
CAIHAKRVTI
130
MPKDIQLARR
IRGERA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000786 |
nucleosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function |
GO:0030527 |
structural constituent of chromatin |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0051382 |
kinetochore assembly |
| Biological Process |
GO:0007080 |
mitotic metaphase chromosome alignment |
| Biological Process |
GO:0006334 |
nucleosome assembly |
| Biological Process |
GO:0030307 |
positive regulation of cell growth |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.