Search Results
Overview
| Uniprot ID | P84586 |
|---|---|
| Protein Name | RNA-binding motif protein, X chromosome retrogene-like |
| Gene Name | Rbmxrtl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | SRGPLPVKRGPPPRS |
| 214 | RDDGYSTKDSYSSRD |
| 30 | ALEAVFGKYGRIVEI |
Function
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity)
Protein Sequence
10
MVEADRPGKL
20
FIGGLNTETN
30
EKALEAVFGK
40
YGRIVEILLM
50
KDRETNKSRG
60
FAFVTFESPA
70
DAKDVARDMN
80
GKSLDGKAIK
90
VEQATKPSFE
100
SGRRGPPPPP
110
RSRGPPRGLR
120
GGSGGTRGPP
130
SRGGYMDDGG
140
YSMNFNMSSS
150
RGPLPVKRGP
160
PPRSGGPPPK
170
RSTPSGPVRS
180
SSGMGGRTPV
190
SRGRDSYGGP
200
PRREPLPSRR
210
DVYLSPRDDG
220
YSTKDSYSSR
230
DYPSSRDTRD
240
YAPPPRDYTY
250
RDYSHSSSRD
260
DYPSRGYGDR
270
DGYGRDREYS
280
DHPSGGSYRD
290
SYESYGNSRS
300
APPTRGPPPS
310
YGGSSRYDDY
320
SSSRDGYGGS
330
RDSYSSSRSD
340
LYSSGRDRVG
350
RQERGLPPSM
360
ERGYPPPRDS
370
YSSSSRGAPR
380
GGGRGGSRSD
RGGGRSRY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0044530 | supraspliceosomal complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0006509 | membrane protein ectodomain proteolysis |
| Biological Process | GO:0006376 | mRNA splice site recognition |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.