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Overview

Uniprot IDP84817
Protein NameMitochondrial fission 1 protein
Gene NameFis1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
46 AWCLVRSKYNDDIRR

Function

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:15979461). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity)

Protein Sequence

10 MEAVLNELVS 20 VEDLKNFERK 30 FQSEQAAGSV 40 SKSTQFEYAW 50 CLVRSKYNDD 60 IRRGIVLLEE 70 LLPKGSKEEQ 80 RDYVFYLAVG 90 NYRLKEYEKA 100 LKYVRGLLQT 110 EPQNNQAKEL 120 ERLIDKAMKK 130 DGLVGMAIVG 140 GMALGVAGLA 150 GLIGLAVSKS KS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0071396 cellular response to lipid
Biological Process GO:1901653 cellular response to peptide
Biological Process GO:0097237 cellular response to toxic substance
Biological Process GO:0000266 mitochondrial fission
Biological Process GO:0043653 mitochondrial fragmentation involved in apoptotic process
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1903579 negative regulation of ATP metabolic process
Biological Process GO:2000192 negative regulation of fatty acid transport
Biological Process GO:0016559 peroxisome fission
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0090141 positive regulation of mitochondrial fission
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0006626 protein targeting to mitochondrion
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:1905395 response to flavonoid
Biological Process GO:1902617 response to fluoride
Biological Process GO:1990910 response to hypobaric hypoxia
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0031667 response to nutrient levels

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.