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Overview

Uniprot ID	P85108
Protein Name	Tubulin beta-2A chain
Gene Name	Tubb2a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
324	FRGRMSMKEVDEQML
58	YNEAAGNKYVPRAIL

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MREIVHIQAG 20 QCGNQIGAKF 30 WEVISDEHGI 40 DPTGSYHGDS 50 DLQLERINVY 60 YNEAAGNKYV 70 PRAILVDLEP 80 GTMDSVRSGP 90 FGQIFRPDNF 100 VFGQSGAGNN 110 WAKGHYTEGA 120 ELVDSVLDVV 130 RKESESCDCL 140 QGFQLTHSLG 150 GGTGSGMGTL 160 LISKIREEYP 170 DRIMNTFSVM 180 PSPKVSDTVV 190 EPYNATLSVH 200 QLVENTDETY 210 SIDNEALYDI 220 CFRTLKLTTP 230 TYGDLNHLVS 240 ATMSGVTTCL 250 RFPGQLNADL 260 RKLAVNMVPF 270 PRLHFFMPGF 280 APLTSRGSQQ 290 YRALTVPELT 300 QQMFDSKNMM 310 AACDPRHGRY 320 LTVAAIFRGR 330 MSMKEVDEQM 340 LNVQNKNSSY 350 FVEWIPNNVK 360 TAVCDIPPRG 370 LKMSATFIGN 380 STAIQELFKR 390 ISEQFTAMFR 400 RKAFLHWYTG 410 EGMDEMEFTE 420 AESNMNDLVS 430 EYQQYQDATA 440 DEQGEFEEEE GEDEA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0015630	microtubule cytoskeleton
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0001764	neuron migration

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.