Search Results
Overview
| Uniprot ID | P85968 |
|---|---|
| Protein Name | 6-phosphogluconate dehydrogenase, decarboxylating |
| Gene Name | Pgd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 308 | SRKLKGPKMVQLEGS |
Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Protein Sequence
10
MAQADIALIG
20
LAVMGQNLIL
30
NMNDHGFVVC
40
AFNRTVSKVD
50
DFLAKEAKGT
60
KVIGAKSLKD
70
MVSKLKKPRR
80
VILLVKAGQA
90
VDDFIEKLVP
100
LLDTGDIIID
110
GGNSEYRDTT
120
RRCQDLKAKG
130
ILFVGSGVSG
140
GEEGARYGPS
150
LMPGGNKEAW
160
PHIKTIFQAI
170
AAKVGTGEPC
180
CDWVGDEGAG
190
HFVKMVHNGI
200
EYGDMQLICE
210
AYHLMKDVLG
220
MRHEEMAQAF
230
EDWNKTELDS
240
FLIEITANIL
250
KFQDTDGKEL
260
LPKIRDSAGQ
270
KGTGKWTAIS
280
ALEYGMPVTL
290
IGEAVFARCL
300
SSLKEERVQA
310
SRKLKGPKMV
320
QLEGSKQAFL
330
EDVRKALYAS
340
KIISYAQGFM
350
LLRQAATEFG
360
WTLNYGGIAL
370
MWRGGCIIRS
380
VFLGKIKDAF
390
ERNPELQNLL
400
LDDFFKSAVD
410
DCQDSWRRVI
420
STGVQAGIPM
430
PCFTTALSFY
440
DGYRHEMLPA
450
NLIQAQRDYF
460
GAHTYELLSK
470
PGEFIHTNWT
480
GHGGSVSSSS
YNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity |
| Biological Process | GO:0019521 | D-gluconate metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0006740 | NADPH regeneration |
| Biological Process | GO:0019322 | pentose biosynthetic process |
| Biological Process | GO:0006098 | pentose-phosphate shunt |
| Biological Process | GO:0009051 | pentose-phosphate shunt, oxidative branch |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.