Search Results
Overview
| Uniprot ID | P85973 |
|---|---|
| Protein Name | Purine nucleoside phosphorylase |
| Gene Name | Pnp |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 265 | QEVLEAGKAAAQKLE |
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity)
Protein Sequence
10
MENEFTYEDY
20
QRTAEWLRSH
30
TKHRPQVAVI
40
CGSGLGGLTA
50
KLTQPQAFDY
60
NEIPNFPQST
70
VQGHAGRLVF
80
GFLNGRSCVM
90
MQGRFHMYEG
100
YSLSKVTFPV
110
RVFHLLGVDT
120
LVVTNAAGGL
130
NPKFEVGDIM
140
LIRDHINLPG
150
FCGQNPLRGP
160
NDERFGVRFP
170
AMSDAYDRDM
180
RQKAFNAWKQ
190
MGEQRELQEG
200
TYIMSAGPTF
210
ETVAESCLLR
220
MLGADAVGMS
230
TVPEVIVARH
240
CGLRVFGFSL
250
ITNKVVMDYN
260
NLEKASHQEV
270
LEAGKAAAQK
280
LEQFVSILME
SIPPRERAN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0034418 | urate biosynthetic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0047975 | guanosine phosphorylase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0001882 | nucleoside binding |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Molecular Function | GO:0002060 | purine nucleobase binding |
| Molecular Function | GO:0004731 | purine-nucleoside phosphorylase activity |
| Biological Process | GO:0000255 | allantoin metabolic process |
| Biological Process | GO:0046059 | dAMP catabolic process |
| Biological Process | GO:0006157 | deoxyadenosine catabolic process |
| Biological Process | GO:0006149 | deoxyinosine catabolic process |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006204 | IMP catabolic process |
| Biological Process | GO:0006148 | inosine catabolic process |
| Biological Process | GO:0006738 | nicotinamide riboside catabolic process |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0009165 | nucleotide biosynthetic process |
| Biological Process | GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
| Biological Process | GO:0043101 | purine-containing compound salvage |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.