Overview
| Uniprot ID | P97351 |
|---|
| Protein Name | Small ribosomal subunit protein eS1 |
|---|
| Gene Name | Rps3a |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 56 |
VTRTQGTKIASDGLK |
Function
Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (PubMed:10713066)
Protein Sequence
10
MAVGKNKRLT
20
KGGKKGAKKK
30
VVDPFSKKDW
40
YDVKAPAMFN
50
IRNIGKTLVT
60
RTQGTKIASD
70
GLKGRVFEVS
80
LADLQNDEVA
90
FRKFKLITED
100
VQGKNCLTNF
110
HGMDLTRDKM
120
CSMVKKWQTM
130
IEAHVDVKTT
140
DGYLLRLFCV
150
GFTKKRNNQI
160
RKTSYAQHQQ
170
VRQIRKKMME
180
IMTREVQTND
190
LKEVVNKLIP
200
DSIGKDIEKA
210
CQSIYPLHDV
220
FVRKVKMLKK
230
PKFELGKLME
240
LHGEGGSSGK
250
AAGDETGAKV
260
ERADGYEPPV
QESV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0048027 |
mRNA 5'-UTR binding |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0002181 |
cytoplasmic translation |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0006412 |
translation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.