Search Results
Overview
| Uniprot ID | P97447 |
|---|---|
| Protein Name | Four and a half LIM domains protein 1 |
| Gene Name | Fhl1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | CVTCHETKFAKHCVK |
| 22 | QGKKYVQKDGRHCCL |
| 278 | VYCPDCAKKL***** |
| 91 | DGKILCNKCATREDS |
Function
May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems
Protein Sequence
10
MSEKFDCHYC
20
RDPLQGKKYV
30
QKDGRHCCLK
40
CFDKFCANTC
50
VDCRKPISAD
60
AKEVHYKNRY
70
WHDNCFRCAK
80
CLHPLASETF
90
VSKDGKILCN
100
KCATREDSPR
110
CKGCFKAIVA
120
GDQNVEYKGT
130
VWHKDCFTCS
140
NCKQVIGTGS
150
FFPKGEDFYC
160
VTCHETKFAK
170
HCVKCNKAIT
180
SGGITYQDQP
190
WHAECFVCVT
200
CSKKLAGQRF
210
TAVEDQYYCV
220
DCYKNFVAKK
230
CAGCKNPITG
240
FGKGSSVVAY
250
EGQSWHDYCF
260
HCKKCSVNLA
270
NKRFVFHNEQ
280
VYCPDCAKKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0099103 | channel activator activity |
| Molecular Function | GO:0099104 | potassium channel activator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| Biological Process | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.