Search Results
Overview
| Uniprot ID | P97450 |
|---|---|
| Protein Name | ATP synthase peripheral stalk subunit F6, mitochondrial |
| Gene Name | Atp5pf |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | PKFEVIDKPQS**** |
| 41 | KELDPVQKLFVDKIR |
| 46 | VQKLFVDKIREYKSK |
| 79 | DRELYKLKQMYGKGE |
| 84 | KLKQMYGKGEMDTFP |
| 94 | MDTFPTFKFDDPKFE |
| 99 | TFKFDDPKFEVIDKP |
Function
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045259 | proton-transporting ATP synthase complex |
| Cellular Component | GO:0097229 | sperm end piece |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism |
| Biological Process | GO:1900139 | negative regulation of arachidonate secretion |
| Biological Process | GO:0032307 | negative regulation of prostaglandin secretion |
| Biological Process | GO:0045777 | positive regulation of blood pressure |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.