Search Results
Overview
| Uniprot ID | P97519 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial |
| Gene Name | Hmgcl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | ASELFTRKNVNCSIE |
Function
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism
Protein Sequence
10
MATVRKAFPQ
20
RLVGLASLRA
30
ASTSSMGTLP
40
KRVKIVEVGP
50
RDGLQNEKSI
60
VPTPVKIKLI
70
DMLSEAGLPV
80
IEATSFVSPK
90
WVPQMADHSD
100
VLKGIQKFPG
110
INYPVLTPNM
120
KGFEEAVAAG
130
AKEVSIFGAA
140
SELFTRKNVN
150
CSIEESFQRF
160
DGVMQAARAA
170
SISVRGYVSC
180
ALGCPYEGKV
190
SPAKVAEVAK
200
KLYSMGCYEI
210
SLGDTIGVGT
220
PGLMKDMLTA
230
VLHEVPVAAL
240
AVHCHDTYGQ
250
ALANTLVALQ
260
MGVSVVDSSV
270
AGLGGCPYAK
280
GASGNLATED
290
LVYMLTGLGI
300
HTGVNLQKLL
310
EAGDFICQAL
320
NRKTSSKVAQ
ATCKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0046951 | ketone body biosynthetic process |
| Biological Process | GO:0006552 | L-leucine catabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0070542 | response to fatty acid |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0042594 | response to starvation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.