Overview
| Uniprot ID | P97521 |
|---|
| Protein Name | Mitochondrial carnitine/acylcarnitine carrier protein |
|---|
| Gene Name | Slc25a20 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 148 |
QASSGKNKYSGTLDC |
Function
Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:9731180). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:8305461)
Protein Sequence
10
MAEEPKPISP
20
LKNLLAGGFG
30
GVCLVFVGHP
40
LDTVKVRLQT
50
QPPSLPGQPP
60
MYSGTIDCFR
70
KTLFREGITG
80
LYRGMAAPII
90
GVTPMFAVCF
100
FGFGLGKRLQ
110
QKSPEDELTY
120
PQLFTAGMLS
130
GVFTTGIMTP
140
GERIKCLLQI
150
QASSGKNKYS
160
GTLDCAKKLY
170
QEFGIRGFYK
180
GTALTLMRDV
190
PASGMYFMTY
200
EWLKNLFTPQ
210
GKSVHDLSVP
220
RVLVAGGFRG
230
IFNWVVAIPP
240
DVLKSRFQTA
250
PPGKYPNGFR
260
DVLRELIREE
270
GVTSLYKGFN
280
AVMIRAFPAN
290
AACFLGFEIP
300
MKILNWIAPN
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005740 |
mitochondrial envelope |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0005476 |
carnitine:O-acyl-L-carnitine antiporter activity |
| Molecular Function |
GO:0015227 |
O-acyl-L-carnitine transmembrane transporter activity |
| Biological Process |
GO:0006853 |
carnitine shuttle |
| Biological Process |
GO:1902603 |
carnitine transmembrane transport |
| Biological Process |
GO:0001701 |
in utero embryonic development |
| Biological Process |
GO:0006839 |
mitochondrial transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.