Overview
| Uniprot ID | P97532 |
|---|
| Protein Name | 3-mercaptopyruvate sulfurtransferase |
|---|
| Gene Name | Mpst |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 40 |
DASWYLPKLGRDARR |
Function
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions
Protein Sequence
10
MAAPQLFRAL
20
VSAQWVAEAL
30
KSPRASQPLK
40
LLDASWYLPK
50
LGRDARREFE
60
ERHIPGAAFF
70
DIDRCSDHTS
80
PYDHMLPSAT
90
HFADYAGSLG
100
VSAATHVVIY
110
DGSDQGLYSA
120
PRVWWMFRAF
130
GHHSVSLLDG
140
GFRYWLSQNL
150
PISSGKSPSE
160
PAEFCAQLDP
170
SFIKTHEDIL
180
ENLDARRFQV
190
VDARAAGRFQ
200
GTQPEPRDGI
210
EPGHIPGSVN
220
IPFTEFLTSE
230
GLEKSPEEIQ
240
RLFQEKKVDL
250
SKPLVATCGS
260
GVTACHVVLG
270
AFLCGKPDVP
280
VYDGSWVEWY
290
MRAQPEHVIS
QGRGKTL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0016784 |
3-mercaptopyruvate sulfurtransferase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004792 |
thiosulfate-cyanide sulfurtransferase activity |
| Biological Process |
GO:0070814 |
hydrogen sulfide biosynthetic process |
| Biological Process |
GO:0001822 |
kidney development |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0021510 |
spinal cord development |
| Biological Process |
GO:0019346 |
transsulfuration |
| Biological Process |
GO:0002143 |
tRNA wobble position uridine thiolation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.