Overview
| Uniprot ID | P97544 |
|---|
| Protein Name | Phospholipid phosphatase 3 |
|---|
| Gene Name | Plpp3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 282 |
VSDLFKTKTTLSLPA |
| 8 |
MQSYKYDKAIVPESK |
Function
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity)
Protein Sequence
10
MQSYKYDKAI
20
VPESKNGGSP
30
ALNNNPRKGG
40
SKRVLLICLD
50
LFCLFMAALP
60
FLIIETSTIK
70
PYRRGFYCND
80
ESIKYPLKVS
90
ETINDAVLCA
100
VGIVIAILRI
110
ITGEFYRIYY
120
LKEKSRSTIQ
130
NPYVAALYKQ
140
VGCFLFGCAI
150
SQSFTDIAKV
160
SIGRLRPHFL
170
SVCDPDFSQI
180
NCSEGYIQNY
190
RCRGEDSKVQ
200
EARKSFFSGH
210
ASFSMFTMLY
220
LVLYLQARFT
230
WRGARLLRPL
240
LQFTLLMMAF
250
YTGLSRVSDY
260
KHHPSDVLAG
270
FAQGALVACC
280
IVFFVSDLFK
290
TKTTLSLPAP
300
AIRREILSPV
310
DIMDRSNHHN
MV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0070971 |
endoplasmic reticulum exit site |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0106235 |
ceramide-1-phosphate phosphatase activity |
| Molecular Function |
GO:0070097 |
delta-catenin binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0042577 |
lipid phosphatase activity |
| Molecular Function |
GO:0008195 |
phosphatidate phosphatase activity |
| Molecular Function |
GO:0042392 |
sphingosine-1-phosphate phosphatase activity |
| Biological Process |
GO:0060020 |
Bergmann glial cell differentiation |
| Biological Process |
GO:0001568 |
blood vessel development |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0033631 |
cell-cell adhesion mediated by integrin |
| Biological Process |
GO:0006672 |
ceramide metabolic process |
| Biological Process |
GO:0001702 |
gastrulation with mouth forming second |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:0046839 |
phospholipid dephosphorylation |
| Biological Process |
GO:0006644 |
phospholipid metabolic process |
| Biological Process |
GO:0010595 |
positive regulation of endothelial cell migration |
| Biological Process |
GO:1904906 |
positive regulation of endothelial cell-matrix adhesion |
| Biological Process |
GO:0034112 |
positive regulation of homotypic cell-cell adhesion |
| Biological Process |
GO:1902533 |
positive regulation of intracellular signal transduction |
| Biological Process |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:1902068 |
regulation of sphingolipid mediated signaling pathway |
| Biological Process |
GO:0030111 |
regulation of Wnt signaling pathway |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0006670 |
sphingosine metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.