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Overview

Uniprot IDP97546
Protein NameNeuroplastin
Gene NameNptn
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
147 ATISVLQKPRIVTSE
243 APDITGHKRSENKNE
248 GHKRSENKNEGQDAM

Function

Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (By similarity). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (PubMed:10759566, PubMed:16925595). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (PubMed:10759566, PubMed:16925595). May play a role in synaptic plasticity (PubMed:10759566, PubMed:16925595). Promotes localization of XKR8 at the cell membrane (By similarity)

Protein Sequence

10 MSGSSLPGAL 20 ALSLLLVSGS 30 LLPGPGAAQN 40 AGFVKSPMSE 50 TKLTGDAFEL 60 YCDVVGSPTP 70 EIQWWYAEVN 80 RAESFRQLWD 90 GARKRRVTVN 100 TAYGSNGVSV 110 LRITRLTLED 120 SGTYECRASN 130 DPKRNDLRQN 140 PSITWIRAQA 150 TISVLQKPRI 160 VTSEEVIIRD 170 SLLPVTLQCN 180 LTSSSHTLMY 190 SYWTKNGVEL 200 TATRKNASNM 210 EYRINKPRAE 220 DSGEYHCVYH 230 FVSAPKANAT 240 IEVKAAPDIT 250 GHKRSENKNE 260 GQDAMMYCKS 270 VGYPHPEWMW 280 RKKENGVFEE 290 ISNSSGRFFI 300 INKENYTELN 310 IVNLQITEDP 320 GEYECNATNS 330 IGSASVSTVL 340 RVRSHLAPLW 350 PFLGILAEII 360 ILVVIIVVYE 370 KRKRPDEVPD 380 AGPMKTNSTN 390 NHKDKNLRQR NTN

Gene Ontology

Classification GO ID Description
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Cellular Component GO:0030424 axon
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030425 dendrite
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0060077 inhibitory synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098839 postsynaptic density membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0048787 presynaptic active zone membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0097060 synaptic membrane
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0098632 cell-cell adhesion mediator activity
Molecular Function GO:0044325 transmembrane transporter binding
Molecular Function GO:0005105 type 1 fibroblast growth factor receptor binding
Biological Process GO:0007411 axon guidance
Biological Process GO:0070593 dendrite self-avoidance
Biological Process GO:1904861 excitatory synapse assembly
Biological Process GO:0007156 homophilic cell-cell adhesion
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0001818 negative regulation of cytokine production
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:0048170 positive regulation of long-term neuronal synaptic plasticity
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:1903829 positive regulation of protein localization
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:1902683 regulation of receptor localization to synapse
Biological Process GO:0050808 synapse organization
Biological Process GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
Biological Process GO:0008542 visual learning

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.