Overview
| Uniprot ID | P97584 |
|---|
| Protein Name | Prostaglandin reductase 1 |
|---|
| Gene Name | Ptgr1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 168 |
IAKLKGCKVVGTAGS |
| 178 |
GTAGSDEKVAYLKKL |
| 197 |
AFNYKTVKSLEEALR |
| 5 |
***MVQAKTWTLKKH |
Function
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (By similarity). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity) (PubMed:11524419). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:11524419). Inactivates 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (PubMed:11524419)
Protein Sequence
10
MVQAKTWTLK
20
KHFEGFPTDS
30
NFELRTTELP
40
PLNNGEVLLE
50
ALFLSVDPYM
60
RVAAKKLKEG
70
DSMMGEQVAR
80
VVESKNSAFP
90
TGTIVVALLG
100
WTSHSISDGN
110
GLRKLPAEWP
120
DKLPLSLALG
130
TVGMPGLTAY
140
FGLLDICGLK
150
GGETVLVNAA
160
AGAVGSVVGQ
170
IAKLKGCKVV
180
GTAGSDEKVA
190
YLKKLGFDVA
200
FNYKTVKSLE
210
EALRTASPDG
220
YDCYFDNVGG
230
EFSNTVILQM
240
KTFGRIAICG
250
AISQYNRTGP
260
CPPGPSPEVI
270
IYQQLRMEGF
280
IVTRWQGEVR
290
QKALTDLMNW
300
VSEGKIRYHE
310
YITEGFEKMP
320
AAFMGMLKGD
NLGKTIVKA
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0035798 |
2-alkenal reductase (NADPH) activity |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0036185 |
13-lipoxin reductase activity |
| Molecular Function |
GO:0047522 |
15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
| Molecular Function |
GO:0097257 |
leukotriene B4 12-hydroxy dehydrogenase activity |
| Biological Process |
GO:0036102 |
leukotriene B4 metabolic process |
| Biological Process |
GO:2001302 |
lipoxin A4 metabolic process |
| Biological Process |
GO:0050928 |
negative regulation of positive chemotaxis |
| Biological Process |
GO:1903427 |
negative regulation of reactive oxygen species biosynthetic process |
| Biological Process |
GO:0006693 |
prostaglandin metabolic process |
| Biological Process |
GO:0097327 |
response to antineoplastic agent |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.