Search Results

Overview

Uniprot IDP97685
Protein NameNeurofascin
Gene NameNfasc
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
123 YQCFARNKFGTALSN
299 AKFENFNKALRITNV

Function

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination

Protein Sequence

10 MARQQAPPWV 20 HVALILFLLS 30 LGGAIEIPMD 40 PSIQNELTQP 50 PTITKQSVKD 60 HIVDPRDNIL 70 IECEAKGNPA 80 PSFHWTRNSR 90 FFNIAKDPRV 100 SMRRRSGTLV 110 IDFRSGGRPE 120 EYEGEYQCFA 130 RNKFGTALSN 140 RIRLQVSKSP 150 LWPKENLDPV 160 VVQEGAPLTL 170 QCNPPPGLPS 180 PVIFWMSSSM 190 EPITQDKRVS 200 QGHNGDLYFS 210 NVMLQDMQTD 220 YSCNARFHFT 230 HTIQQKNPFT 240 LKVLTTRGVA 250 ERTPSFMYPQ 260 GTSSSQMVLR 270 GMDLLLECIA 280 SGVPTPDIAW 290 YKKGGDLPSD 300 KAKFENFNKA 310 LRITNVSEED 320 SGEYFCLASN 330 KMGSIRHTIS 340 VRVKAAPYWL 350 DEPKNLILAP 360 GEDGRLVCRA 370 NGNPKPTVQW 380 LVNGDPLQSA 390 PPNPNREVAG 400 DTIIFRDTQI 410 SSRAVYQCNT 420 SNEHGYLLAN 430 AFVSVLDVPP 440 RMLSPRNQLI 450 RVILYNRTRL 460 DCPFFGSPIP 470 TLRWFKNGQG 480 SNLDGGNYHV 490 YENGSLEIKM 500 IRKEDQGIYT 510 CVATNILGKA 520 ENQVRLEVKD 530 PTRIYRMPED 540 QVAKRGTTVQ 550 LECRVKHDPS 560 LKLTVSWLKD 570 DEPLYIGNRM 580 KKEDDSLTIF 590 GVAERDQGSY 600 TCMASTELDQ 610 DLAKAYLTVL 620 ADQATPTNRL 630 AALPKGRPDR 640 PRDLELTDLA 650 ERSVRLTWIP 660 GDDNNSPITD 670 YVVQFEEDQF 680 QPGVWHDHSK 690 FPGSVNSAVL 700 HLSPYVNYQF 710 RVIAVNEVGS 720 SHPSLPSERY 730 RTSGAPPESN 740 PSDVKGEGTR 750 KNNMEITWTP 760 MNATSAFGPN 770 LRYIVKWRRR 780 ETRETWNNVT 790 VWGSRYVVGQ 800 TPVYVPYEIR 810 VQAENDFGKG 820 PEPETVIGYS 830 GEDLPSAPRR 840 FRVRQPNLET 850 INLEWDHPEH 860 PNGILIGYTL 870 RYVPFNGTKL 880 GKQMVENFSP 890 NQTKFSVQRA 900 DPVSRYRFSL 910 SARTQVGSGE 920 AATEESPTPP 930 NEATPTAAPP 940 TLPPTTVGTT 950 GLVSSTDATA 960 LAATSEATTV 970 PIIPTVVPTT 980 VATTIATTTT 990 TTAAATTTTT 1000 TESPPTTTTG 1010 TKIHETAPDE 1020 QSIWNVTVLP 1030 NSKWANITWK 1040 HNFRPGTDFV 1050 VEYIDSNHTK 1060 KTVPVKAQAQ 1070 PIQLTDLFPG 1080 MTYTLRVYSR 1090 DNEGISSTVI 1100 TFMTSTAYTN 1110 NQTDIATQGW 1120 FIGLMCAIAL 1130 LVLILLIVCF 1140 IKRSRGGKYP 1150 VREKKDVPLG 1160 PEDPKEEDGS 1170 FDYSDEDNKP 1180 LQGSQTSLDG 1190 TIKQQESDDS 1200 LVDYGEGGEG 1210 QFNEDGSFIG 1220 QYTVRKDKEE 1230 TEGNESSEAT 1240 SPVNAIYSLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0043194 axon initial segment
Cellular Component GO:0030425 dendrite
Cellular Component GO:0033268 node of Ranvier
Cellular Component GO:0033010 paranodal junction
Cellular Component GO:0033270 paranode region of axon
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0097454 Schwann cell microvillus
Molecular Function GO:0098632 cell-cell adhesion mediator activity
Molecular Function GO:0086080 protein binding involved in heterotypic cell-cell adhesion
Molecular Function GO:0019904 protein domain specific binding
Biological Process GO:0007411 axon guidance
Biological Process GO:0007420 brain development
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0045162 clustering of voltage-gated sodium channels
Biological Process GO:0042552 myelination
Biological Process GO:0030913 paranodal junction assembly
Biological Process GO:0007422 peripheral nervous system development
Biological Process GO:0071205 protein localization to juxtaparanode region of axon
Biological Process GO:0002175 protein localization to paranode region of axon
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0050808 synapse organization
Biological Process GO:0019226 transmission of nerve impulse

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.