Overview
| Uniprot ID | P97697 |
|---|
| Protein Name | Inositol monophosphatase 1 |
|---|
| Gene Name | Impa1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 30 |
IREALKNKMDVMIKS |
| 49 |
LVTVTDQKVEKMLMS |
Function
Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol (PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (By similarity). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate (PubMed:9462881)
Protein Sequence
10
MADPWQECMD
20
YAVILARQAG
30
EMIREALKNK
40
MDVMIKSSPA
50
DLVTVTDQKV
60
EKMLMSSIKE
70
KYPYHSFIGE
80
ESVASGEKTV
90
FTEQPTWIID
100
PIDGTTNFVH
110
RFPFVAVSIG
120
FVVNKEMEFG
130
VVYSCVEDKM
140
YTGRKGKGAF
150
CNGQKLRVSQ
160
QEDITKSLLV
170
TELGSSRKPE
180
TLRIVLSNME
190
RLCSIPIHGI
200
RSVGTAAVNM
210
CLVATGGADA
220
YYEMGIHCWD
230
MAGAGIIVIE
240
AGGVLLDVTG
250
GPFDLMSRRI
260
IAASNIALAE
270
RIAKELEIIP
LQRDDES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Molecular Function |
GO:0103026 |
fructose-1-phosphatase activity |
| Molecular Function |
GO:0008877 |
glucose-1-phosphatase activity |
| Molecular Function |
GO:0004346 |
glucose-6-phosphatase activity |
| Molecular Function |
GO:0047954 |
glycerol-2-phosphatase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008934 |
inositol monophosphate 1-phosphatase activity |
| Molecular Function |
GO:0052832 |
inositol monophosphate 3-phosphatase activity |
| Molecular Function |
GO:0052833 |
inositol monophosphate 4-phosphatase activity |
| Molecular Function |
GO:0052834 |
inositol monophosphate phosphatase activity |
| Molecular Function |
GO:0031403 |
lithium ion binding |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0030145 |
manganese ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006021 |
inositol biosynthetic process |
| Biological Process |
GO:0006020 |
inositol metabolic process |
| Biological Process |
GO:0006796 |
phosphate-containing compound metabolic process |
| Biological Process |
GO:0006661 |
phosphatidylinositol biosynthetic process |
| Biological Process |
GO:0046854 |
phosphatidylinositol phosphate biosynthetic process |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.