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Overview

Uniprot IDP97710
Protein NameTyrosine-protein phosphatase non-receptor type substrate 1
Gene NameSirpa
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
127 YYCVKFQKGIVEPDT
417 TRLHEPEKNAREITQ

Function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (PubMed:24511121). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121)

Protein Sequence

10 MEPAGPAPGR 20 LGPLLFCLLL 30 SASCFCAGAS 40 GKELKVTQAD 50 KSVSVAAGDS 60 ATLNCTVSSL 70 TPVGPIKWFK 80 GEGQNRSPIY 90 SFIGGEHFPR 100 ITNVSDATKR 110 NNMDFSICIS 120 NVTPEDAGTY 130 YCVKFQKGIV 140 EPDTEIKSGG 150 GTTLYVLAKP 160 SSPEVSGPDS 170 RGSPGQTVNF 180 TCKSYGFSPR 190 NITLKWLKDG 200 KELSHLETTI 210 SSKSNVSYNI 220 SSTVSVKLSP 230 EDIHSRVICE 240 VAHVTLEGRP 250 LNGTANFSNI 260 IRVSPTLKIT 270 QQPLTPASQV 280 NLTCQVQKFY 290 PKALQLNWLE 300 NGNLSRTDKP 310 EHFTDNRDGT 320 YNYTSLFLVN 330 SSAHREDVVF 340 TCQVEHDSQP 350 AITENHTVRA 360 FAHSSSGGSM 370 ETIPDNNAYY 380 NWNVFIGVGV 390 ACALLVVLLM 400 AALYLLRIKQ 410 KKAKGSTSST 420 RLHEPEKNAR 430 EITQIQDTND 440 INDITYADLN 450 LPKEKKPAPR 460 VPEPNNHTEY 470 ASIETGKLPR 480 PEDTLTYADL 490 DMVHLNRAQP 500 TPKPEPSFSE YASVQVQRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0098632 cell-cell adhesion mediator activity
Molecular Function GO:0030695 GTPase regulator activity
Molecular Function GO:1990405 protein antigen binding
Molecular Function GO:0086080 protein binding involved in heterotypic cell-cell adhesion
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Molecular Function GO:0045309 protein phosphorylated amino acid binding
Molecular Function GO:1990782 protein tyrosine kinase binding
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0016477 cell migration
Biological Process GO:0048870 cell motility
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071349 cellular response to interleukin-12
Biological Process GO:0071346 cellular response to type II interferon
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0097530 granulocyte migration
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0035696 monocyte extravasation
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032688 negative regulation of interferon-beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
Biological Process GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
Biological Process GO:0045019 negative regulation of nitric oxide biosynthetic process
Biological Process GO:0050765 negative regulation of phagocytosis
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0006910 phagocytosis, recognition
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0050870 positive regulation of T cell activation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0032651 regulation of interleukin-1 beta production
Biological Process GO:0032675 regulation of interleukin-6 production
Biological Process GO:0045428 regulation of nitric oxide biosynthetic process
Biological Process GO:0032680 regulation of tumor necrosis factor production
Biological Process GO:0032649 regulation of type II interferon production

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.