Search Results
Overview
| Uniprot ID | P97756 |
|---|---|
| Protein Name | Calcium/calmodulin-dependent protein kinase kinase 1 |
| Gene Name | Camkk1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 136 | KLQSEIGKGAYGVVR |
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death
Protein Sequence
10
MERSPAVCCQ
20
DPRAELVERV
30
AAISVAHLEE
40
AEEGPEPASN
50
GVDPPPRARA
60
ASVIPGSASR
70
PTPVRPSLSA
80
RKFSLQERPA
90
GSCLEAQVGP
100
YSTGPASHMS
110
PRAWRRPTIE
120
SHHVAISDTE
130
DCVQLNQYKL
140
QSEIGKGAYG
150
VVRLAYNERE
160
DRHYAMKVLS
170
KKKLLKQYGF
180
PRRPPPRGSQ
190
APQGGPAKQL
200
LPLERVYQEI
210
AILKKLDHVN
220
VVKLIEVLDD
230
PAEDNLYLVF
240
DLLRKGPVME
250
VPCDKPFPEE
260
QARLYLRDII
270
LGLEYLHCQK
280
IVHRDIKPSN
290
LLLGDDGHVK
300
IADFGVSNQF
310
EGNDAQLSST
320
AGTPAFMAPE
330
AISDTGQSFS
340
GKALDVWATG
350
VTLYCFVYGK
360
CPFIDEYILA
370
LHRKIKNEAV
380
VFPEEPEVSE
390
ELKDLILKML
400
DKNPETRIGV
410
SDIKLHPWVT
420
KHGEEPLPSE
430
EEHCSVVEVT
440
EEEVKNSVKL
450
IPSWTTVILV
460
KSMLRKRSFG
470
NPFEPQARRE
480
ERSMSAPGNL
490
LLKEGCGEGG
500
KSPELPGVQE
DEAAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004683 | calcium/calmodulin-dependent protein kinase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Biological Process | GO:0032147 | activation of protein kinase activity |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:0006468 | protein phosphorylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.