Search Results

Overview

Uniprot IDP97837
Protein NameDisks large-associated protein 2
Gene NameDlgap2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
614 AVSYTNYKKTPPPVP

Function

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

Protein Sequence

10 MGTAQVLPGI 20 LQKHCCILPD 30 RNTESQCTLC 40 GEPEEEEGGD 50 LAQPGLSFPG 60 PAEEDIDQQY 70 SWSPTQHFSE 80 ERYSPAPRNM 90 KGLTGSRNQP 100 QLCVGHTCGL 110 SPTDECEHPH 120 DHVRHGPDVR 130 QPYLLSPAES 140 CPMDHHRCSP 150 RSSVHSECMM 160 MPVMLGDHVS 170 SSTFPRMHYS 180 SHYDTRDDCA 190 TSHASTKVNR 200 IPANLLDQFE 210 KQLPLHRDGF 220 HTLQYHRASA 230 ATEQRNESPG 240 RIRHLVHSVQ 250 KLFTKSHSLE 260 GSSKSNINGT 270 KSEGRMDDHH 280 QSHLSKHSKR 290 SKSKERKPES 300 KHKSGMSSWW 310 SSDDNLDSDS 320 TYRTPSVAHR 330 HHMDHIPHCY 340 PEALQSPFGD 350 LSLKTSKSNS 360 DVKCSACEGL 370 ALTPDTRYMK 380 RSSWSTLTVS 390 QAKEAYRKSS 400 LNLDKPLVHP 410 EIKPSLQPCH 420 YLQVPQDDWG 430 AYPTGGKEEE 440 IPCRRMRSGS 450 YIKAMGDEES 460 GESDSSPKTS 470 PTVALRPEPL 480 LKSIIQRPLG 490 DHQTQSYLQA 500 ATEVPVGHSL 510 DPSVNYNSPK 520 FRSRNQSYMR 530 AVSTLSQASC 540 VSQMSEAEVN 550 GQFESVCESV 560 FSEVESQAMD 570 ALDLPGCFRT 580 RSHSYLRAIQ 590 AGYSQDDECI 600 PVMTPSNMTS 610 TIRSTAAVSY 620 TNYKKTPPPV 630 PPRTTSKPLI 640 SVTAQSSTES 650 TQDAYQDSRA 660 QRMSPWPQDS 670 RGGLYNSMDS 680 LDSNKAMNLA 690 LESAAAQRHA 700 ADTQSSSTRS 710 IDKAVLVSKA 720 EELLKSRCSS 730 IGVQDSEFPD 740 HQPYPRSDVE 750 TATDSDTESR 760 GLREYHSVGV 770 QVEDEKRHGR 780 FKRSNSVTAA 790 VQADLELEGF 800 PGHVSMEDKG 810 LQFGSSFQRH 820 SEPSTPTQYG 830 ALRTVRTQGL 840 FSYREDYRTQ 850 VDTSTLPPPD 860 PWLEPSLDTV 870 ETGRMSPCRR 880 DGSWFLKLLH 890 TETKKMEGWC 900 KEMEREAEEN 910 DLSEEILGKI 920 RSAVGSAQLL 930 MSQKFQQFYW 940 LCQQNMDPSA 950 MPRPTSQDLA 960 GYWDMLQLSV 970 EDVSMKFDEL 980 HQLKLNDWKI 990 MESPERKEER 1000 KIPPPIPKKP 1010 PKGKFPITRE 1020 KSLDLPDRQR 1030 QEARRRLMAA 1040 KRAASFRQNS 1050 ATERADSIEI YIPEAQTRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005883 neurofilament
Cellular Component GO:0099092 postsynaptic density, intracellular component
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0099572 postsynaptic specialization
Molecular Function GO:0004385 GMP kinase activity
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0019904 protein domain specific binding
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0007270 neuron-neuron synaptic transmission

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.