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Overview

Uniprot IDP97849
Protein NameLong-chain fatty acid transport protein 1
Gene NameSlc27a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
598 VDTTGTFKIQKTRLQ

Function

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:19380575). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier (By similarity)

Protein Sequence

10 MRTPGAGTAS 20 VASLGLLWLL 30 GLPWTWSAAA 40 AFGVYVGSGG 50 WRFLRIVCKT 60 ARRDLFGLSV 70 LIRVRLELRR 80 HRRAGDTIPR 90 IFQAVAQRQP 100 ERLALVDASS 110 GICWTFAQLD 120 TYSNAVANLF 130 LQLGFAPGDV 140 VAVFLEGRPE 150 FVGLWLGLAK 160 AGVVAALLNV 170 NLRREPLAFC 180 LGTSAAKALI 190 YGGEMAAAVA 200 EVSEQLGKSL 210 LKFCSGDLGP 220 ESVLPDTQLL 230 DPMLAEAPTT 240 PLAQAPGKGM 250 DDRLFYIYTS 260 GTTGLPKAAI 270 VVHSRYYRIA 280 AFGHHSYSMR 290 ANDVLYDCLP 300 LYHSAGNIMG 310 VGQCIIYGLT 320 VVLRKKFSAS 330 RFWDDCVKYN 340 CTVVQYIGEI 350 CRYLLRQPVR 360 DVERRHRVRL 370 AVGNGLRPAI 380 WEEFTQGFGV 390 RQIGEFYGAT 400 ECNCSIANMD 410 GKVGSCGFNS 420 RILTHVYPIR 430 LVKVNEDTME 440 PLRDSQGLCI 450 PCQPGEPGLL 460 VGQINQQDPL 470 RRFDGYVSDS 480 ATNKKIAHSV 490 FRKGDSAYLS 500 GDVLVMDELG 510 YMYFRDRSGD 520 TFRWRGENVS 530 TTEVEAVLSR 540 LLGQTDVAVY 550 GVAVPGVEGK 560 SGMAAIADPH 570 NQLDPNSMYQ 580 ELQKVLASYA 590 QPIFLRLLPQ 600 VDTTGTFKIQ 610 KTRLQREGFD 620 PRQTSDRLFF 630 LDLKQGRYLP 640 LDERVHARIC AGDFSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009925 basal plasma membrane
Biological Process GO:0032868 response to insulin
Cellular Component GO:0005901 caveola
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0047676 arachidonate-CoA ligase activity
Molecular Function GO:0015225 biotin transmembrane transporter activity
Molecular Function GO:0015562 efflux transmembrane transporter activity
Molecular Function GO:0015245 fatty acid transmembrane transporter activity
Molecular Function GO:0071714 icosanoid transmembrane transporter activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005324 long-chain fatty acid transmembrane transporter activity
Molecular Function GO:0004467 long-chain fatty acid-CoA ligase activity
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0090434 oleoyl-CoA ligase activity
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Molecular Function GO:0031957 very long-chain fatty acid-CoA ligase activity
Biological Process GO:0033211 adiponectin-activated signaling pathway
Biological Process GO:1905135 biotin import across plasma membrane
Biological Process GO:0015878 biotin transport
Biological Process GO:0140115 export across plasma membrane
Biological Process GO:0015908 fatty acid transport
Biological Process GO:0044381 glucose import in response to insulin stimulus
Biological Process GO:1990379 lipid transport across blood-brain barrier
Biological Process GO:0015911 long-chain fatty acid import across plasma membrane
Biological Process GO:0044539 long-chain fatty acid import into cell
Biological Process GO:0001676 long-chain fatty acid metabolic process
Biological Process GO:0015909 long-chain fatty acid transport
Biological Process GO:0001579 medium-chain fatty acid transport
Biological Process GO:0031652 positive regulation of heat generation
Biological Process GO:0010867 positive regulation of triglyceride biosynthetic process
Biological Process GO:0009409 response to cold

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.