Search Results
Overview
| Uniprot ID | P97887 |
|---|---|
| Protein Name | Presenilin-1 |
| Gene Name | Psen1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 314 | RRVPKNPKYSTQGTE |
Function
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity (By similarity). It acts through the control of SYT7 presynaptic expression (PubMed:30429473)
Protein Sequence
10
MTEIPAPLSY
20
FQNAQMSEDS
30
HSSSVRSQND
40
NQERQQHHDR
50
QRLDNPESIS
60
NGRPQSNFTR
70
QVIEQDEEED
80
EELTLKYGAK
90
HVIMLFVPVT
100
LCMVVVVATI
110
KSVSFYTRKD
120
GQLIYTPFTE
130
DTETVGQRAL
140
HSILNAAIMI
150
SVIVVMTILL
160
VVLYKYRCYK
170
VIHAWLIVSS
180
LLLLFFFSFI
190
YLGEVFKTYN
200
VAVDYITVAL
210
LIWNFGVVGM
220
IAIHWKGPLR
230
LQQAYLIMIS
240
ALMALVFIKY
250
LPEWTAWLIL
260
AVISVYDLVA
270
VLCPKGPLRM
280
LVETAQERNE
290
TLFPALIYSS
300
TMVWLVNMAE
310
GDPEAQRRVP
320
KNPKYSTQGT
330
EREETQDTGT
340
GSDDGGFSEE
350
WEAQRDSHLG
360
PHRSTPESRA
370
AVQELSGSIL
380
TSEDPEERGV
390
KLGLGDFIFY
400
SVLVGKASAT
410
ASGDWNTTIA
420
CFVAILIGLC
430
LTLLLLAIFK
440
KALPALPISI
450
TFGLIFYFAT
460
DYLVQPFMDQ
LAFHQFYI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016235 | aggresome |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0035253 | ciliary rootlet |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070765 | gamma-secretase complex |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0044233 | mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005640 | nuclear outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005791 | rough endoplasmic reticulum |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving |
| Molecular Function | GO:0004190 | aspartic-type endopeptidase activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Molecular Function | GO:0070851 | growth factor receptor binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0042987 | amyloid precursor protein catabolic process |
| Biological Process | GO:0042982 | amyloid precursor protein metabolic process |
| Biological Process | GO:0034205 | amyloid-beta formation |
| Biological Process | GO:0050435 | amyloid-beta metabolic process |
| Biological Process | GO:0048143 | astrocyte activation |
| Biological Process | GO:0002265 | astrocyte activation involved in immune response |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0001568 | blood vessel development |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0048854 | brain morphogenesis |
| Biological Process | GO:0021870 | Cajal-Retzius cell differentiation |
| Biological Process | GO:0055074 | calcium ion homeostasis |
| Biological Process | GO:0001708 | cell fate specification |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0021795 | cerebral cortex cell migration |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0015871 | choline transport |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0021904 | dorsal/ventral neural tube patterning |
| Biological Process | GO:0030326 | embryonic limb morphogenesis |
| Biological Process | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
| Biological Process | GO:0050673 | epithelial cell proliferation |
| Biological Process | GO:0042462 | eye photoreceptor cell development |
| Biological Process | GO:0030900 | forebrain development |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0009101 | glycoprotein biosynthetic process |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0001947 | heart looping |
| Biological Process | GO:0002244 | hematopoietic progenitor cell differentiation |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0098712 | L-glutamate import across plasma membrane |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0040011 | locomotion |
| Biological Process | GO:0006509 | membrane protein ectodomain proteolysis |
| Biological Process | GO:0031293 | membrane protein intracellular domain proteolysis |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0006839 | mitochondrial transport |
| Biological Process | GO:0043011 | myeloid dendritic cell differentiation |
| Biological Process | GO:0002573 | myeloid leukocyte differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2001234 | negative regulation of apoptotic signaling pathway |
| Biological Process | GO:0050771 | negative regulation of axonogenesis |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0003407 | neural retina development |
| Biological Process | GO:0022008 | neurogenesis |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:1990535 | neuron projection maintenance |
| Biological Process | GO:0007220 | Notch receptor processing |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:1905908 | positive regulation of amyloid fibril formation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0050820 | positive regulation of coagulation |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
| Biological Process | GO:0002038 | positive regulation of L-glutamate import across plasma membrane |
| Biological Process | GO:0043406 | positive regulation of MAP kinase activity |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0140249 | protein catabolic process at postsynapse |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0016485 | protein processing |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0060828 | regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0010975 | regulation of neuron projection development |
| Biological Process | GO:0099175 | regulation of postsynapse organization |
| Biological Process | GO:0060075 | regulation of resting membrane potential |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0035282 | segmentation |
| Biological Process | GO:0048705 | skeletal system morphogenesis |
| Biological Process | GO:0043589 | skin morphogenesis |
| Biological Process | GO:0051563 | smooth endoplasmic reticulum calcium ion homeostasis |
| Biological Process | GO:0001756 | somitogenesis |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0016080 | synaptic vesicle targeting |
| Biological Process | GO:0002286 | T cell activation involved in immune response |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0048538 | thymus development |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.