Search Results

Overview

Uniprot IDP98160
Protein NameBasement membrane-specific heparan sulfate proteoglycan core protein
Gene NameHSPG2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
4023 VSAERLNKDGSLRVN

Function

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (PubMed:12435733, PubMed:15591058, PubMed:19789387). In muscle, it is essential for localizing acetylcholinesterase (AChE) at the neuromuscular junctions (NMJ), most probably acting as an adapter that links the acetylcholinesterase collagenic tail peptide (COLQ) to alpha-dystroglycan, and is therefore involved in the down-regulation of colinergic synaptic transmission (By similarity)

Protein Sequence

10 MGWRAAGALL 20 LALLLHGRLL 30 AVTHGLRAYD 40 GLSLPEDIET 50 VTASQMRWTH 60 SYLSDDEDML 70 ADSISGDDLG 80 SGDLGSGDFQ 90 MVYFRALVNF 100 TRSIEYSPQL 110 EDAGSREFRE 120 VSEAVVDTLE 130 SEYLKIPGDQ 140 VVSVVFIKEL 150 DGWVFVELDV 160 GSEGNADGAQ 170 IQEMLLRVIS 180 SGSVASYVTS 190 PQGFQFRRLG 200 TVPQFPRACT 210 EAEFACHSYN 220 ECVALEYRCD 230 RRPDCRDMSD 240 ELNCEEPVLG 250 ISPTFSLLVE 260 TTSLPPRPET 270 TIMRQPPVTH 280 APQPLLPGSV 290 RPLPCGPQEA 300 ACRNGHCIPR 310 DYLCDGQEDC 320 EDGSDELDCG 330 PPPPCEPNEF 340 PCGNGHCALK 350 LWRCDGDFDC 360 EDRTDEANCP 370 TKRPEEVCGP 380 TQFRCVSTNM 390 CIPASFHCDE 400 ESDCPDRSDE 410 FGCMPPQVVT 420 PPRESIQASR 430 GQTVTFTCVA 440 IGVPTPIINW 450 RLNWGHIPSH 460 PRVTVTSEGG 470 RGTLIIRDVK 480 ESDQGAYTCE 490 AMNARGMVFG 500 IPDGVLELVP 510 QRGPCPDGHF 520 YLEHSAACLP 530 CFCFGITSVC 540 QSTRRFRDQI 550 RLRFDQPDDF 560 KGVNVTMPAQ 570 PGTPPLSSTQ 580 LQIDPSLHEF 590 QLVDLSRRFL 600 VHDSFWALPE 610 QFLGNKVDSY 620 GGSLRYNVRY 630 ELARGMLEPV 640 QRPDVVLMGA 650 GYRLLSRGHT 660 PTQPGALNQR 670 QVQFSEEHWV 680 HESGRPVQRA 690 ELLQVLQSLE 700 AVLIQTVYNT 710 KMASVGLSDI 720 AMDTTVTHAT 730 SHGRAHSVEE 740 CRCPIGYSGL 750 SCESCDAHFT 760 RVPGGPYLGT 770 CSGCNCNGHA 780 SSCDPVYGHC 790 LNCQHNTEGP 800 QCNKCKAGFF 810 GDAMKATATS 820 CRPCPCPYID 830 ASRRFSDTCF 840 LDTDGQATCD 850 ACAPGYTGRR 860 CESCAPGYEG 870 NPIQPGGKCR 880 PVNQEIVRCD 890 ERGSMGTSGE 900 ACRCKNNVVG 910 RLCNECADGS 920 FHLSTRNPDG 930 CLKCFCMGVS 940 RHCTSSSWSR 950 AQLHGASEEP 960 GHFSLTNAAS 970 THTTNEGIFS 980 PTPGELGFSS 990 FHRLLSGPYF 1000 WSLPSRFLGD 1010 KVTSYGGELR 1020 FTVTQRSQPG 1030 STPLHGQPLV 1040 VLQGNNIILE 1050 HHVAQEPSPG 1060 QPSTFIVPFR 1070 EQAWQRPDGQ 1080 PATREHLLMA 1090 LAGIDTLLIR 1100 ASYAQQPAES 1110 RVSGISMDVA 1120 VPEETGQDPA 1130 LEVEQCSCPP 1140 GYRGPSCQDC 1150 DTGYTRTPSG 1160 LYLGTCERCS 1170 CHGHSEACEP 1180 ETGACQGCQH 1190 HTEGPRCEQC 1200 QPGYYGDAQR 1210 GTPQDCQLCP 1220 CYGDPAAGQA 1230 AHTCFLDTDG 1240 HPTCDACSPG 1250 HSGRHCERCA 1260 PGYYGNPSQG 1270 QPCQRDSQVP 1280 GPIGCNCDPQ 1290 GSVSSQCDAA 1300 GQCQCKAQVE 1310 GLTCSHCRPH 1320 HFHLSASNPD 1330 GCLPCFCMGI 1340 TQQCASSAYT 1350 RHLISTHFAP 1360 GDFQGFALVN 1370 PQRNSRLTGE 1380 FTVEPVPEGA 1390 QLSFGNFAQL 1400 GHESFYWQLP 1410 ETYQGDKVAA 1420 YGGKLRYTLS 1430 YTAGPQGSPL 1440 SDPDVQITGN 1450 NIMLVASQPA 1460 LQGPERRSYE 1470 IMFREEFWRR 1480 PDGQPATREH 1490 LLMALADLDE 1500 LLIRATFSSV 1510 PLAASISAVS 1520 LEVAQPGPSN 1530 RPRALEVEEC 1540 RCPPGYIGLS 1550 CQDCAPGYTR 1560 TGSGLYLGHC 1570 ELCECNGHSD 1580 LCHPETGACS 1590 QCQHNAAGEF 1600 CELCAPGYYG 1610 DATAGTPEDC 1620 QPCACPLTNP 1630 ENMFSRTCES 1640 LGAGGYRCTA 1650 CEPGYTGQYC 1660 EQCGPGYVGN 1670 PSVQGGQCLP 1680 ETNQAPLVVE 1690 VHPARSIVPQ 1700 GGSHSLRCQV 1710 SGSPPHYFYW 1720 SREDGRPVPS 1730 GTQQRHQGSE 1740 LHFPSVQPSD 1750 AGVYICTCRN 1760 LHQSNTSRAE 1770 LLVTEAPSKP 1780 ITVTVEEQRS 1790 QSVRPGADVT 1800 FICTAKSKSP 1810 AYTLVWTRLH 1820 NGKLPTRAMD 1830 FNGILTIRNV 1840 QLSDAGTYVC 1850 TGSNMFAMDQ 1860 GTATLHVQAS 1870 GTLSAPVVSI 1880 HPPQLTVQPG 1890 QLAEFRCSAT 1900 GSPTPTLEWT 1910 GGPGGQLPAK 1920 AQIHGGILRL 1930 PAVEPTDQAQ 1940 YLCRAHSSAG 1950 QQVARAVLHV 1960 HGGGGPRVQV 1970 SPERTQVHAG 1980 RTVRLYCRAA 1990 GVPSATITWR 2000 KEGGSLPPQA 2010 RSERTDIATL 2020 LIPAITTADA 2030 GFYLCVATSP 2040 AGTAQARIQV 2050 VVLSASDASP 2060 PPVKIESSSP 2070 SVTEGQTLDL 2080 NCVVAGSAHA 2090 QVTWYRRGGS 2100 LPPHTQVHGS 2110 RLRLPQVSPA 2120 DSGEYVCRVE 2130 NGSGPKEASI 2140 TVSVLHGTHS 2150 GPSYTPVPGS 2160 TRPIRIEPSS 2170 SHVAEGQTLD 2180 LNCVVPGQAH 2190 AQVTWHKRGG 2200 SLPARHQTHG 2210 SLLRLHQVTP 2220 ADSGEYVCHV 2230 VGTSGPLEAS 2240 VLVTIEASVI 2250 PGPIPPVRIE 2260 SSSSTVAEGQ 2270 TLDLSCVVAG 2280 QAHAQVTWYK 2290 RGGSLPARHQ 2300 VRGSRLYIFQ 2310 ASPADAGQYV 2320 CRASNGMEAS 2330 ITVTVTGTQG 2340 ANLAYPAGST 2350 QPIRIEPSSS 2360 QVAEGQTLDL 2370 NCVVPGQSHA 2380 QVTWHKRGGS 2390 LPVRHQTHGS 2400 LLRLYQASPA 2410 DSGEYVCRVL 2420 GSSVPLEASV 2430 LVTIEPAGSV 2440 PALGVTPTVR 2450 IESSSSQVAE 2460 GQTLDLNCLV 2470 AGQAHAQVTW 2480 HKRGGSLPAR 2490 HQVHGSRLRL 2500 LQVTPADSGE 2510 YVCRVVGSSG 2520 TQEASVLVTI 2530 QQRLSGSHSQ 2540 GVAYPVRIES 2550 SSASLANGHT 2560 LDLNCLVASQ 2570 APHTITWYKR 2580 GGSLPSRHQI 2590 VGSRLRIPQV 2600 TPADSGEYVC 2610 HVSNGAGSRE 2620 TSLIVTIQGS 2630 GSSHVPSVSP 2640 PIRIESSSPT 2650 VVEGQTLDLN 2660 CVVARQPQAI 2670 ITWYKRGGSL 2680 PSRHQTHGSH 2690 LRLHQMSVAD 2700 SGEYVCRANN 2710 NIDALEASIV 2720 ISVSPSAGSP 2730 SAPGSSMPIR 2740 IESSSSHVAE 2750 GETLDLNCVV 2760 PGQAHAQVTW 2770 HKRGGSLPSH 2780 HQTRGSRLRL 2790 HHVSPADSGE 2800 YVCRVMGSSG 2810 PLEASVLVTI 2820 EASGSSAVHV 2830 PAPGGAPPIR 2840 IEPSSSRVAE 2850 GQTLDLKCVV 2860 PGQAHAQVTW 2870 HKRGGNLPAR 2880 HQVHGPLLRL 2890 NQVSPADSGE 2900 YSCQVTGSSG 2910 TLEASVLVTI 2920 EPSSPGPIPA 2930 PGLAQPIYIE 2940 ASSSHVTEGQ 2950 TLDLNCVVPG 2960 QAHAQVTWYK 2970 RGGSLPARHQ 2980 THGSQLRLHL 2990 VSPADSGEYV 3000 CRAASGPGPE 3010 QEASFTVTVP 3020 PSEGSSYRLR 3030 SPVISIDPPS 3040 STVQQGQDAS 3050 FKCLIHDGAA 3060 PISLEWKTRN 3070 QELEDNVHIS 3080 PNGSIITIVG 3090 TRPSNHGTYR 3100 CVASNAYGVA 3110 QSVVNLSVHG 3120 PPTVSVLPEG 3130 PVWVKVGKAV 3140 TLECVSAGEP 3150 RSSARWTRIS 3160 STPAKLEQRT 3170 YGLMDSHAVL 3180 QISSAKPSDA 3190 GTYVCLAQNA 3200 LGTAQKQVEV 3210 IVDTGAMAPG 3220 APQVQAEEAE 3230 LTVEAGHTAT 3240 LRCSATGSPA 3250 PTIHWSKLRS 3260 PLPWQHRLEG 3270 DTLIIPRVAQ 3280 QDSGQYICNA 3290 TSPAGHAEAT 3300 IILHVESPPY 3310 ATTVPEHASV 3320 QAGETVQLQC 3330 LAHGTPPLTF 3340 QWSRVGSSLP 3350 GRATARNELL 3360 HFERAAPEDS 3370 GRYRCRVTNK 3380 VGSAEAFAQL 3390 LVQGPPGSLP 3400 ATSIPAGSTP 3410 TVQVTPQLET 3420 KSIGASVEFH 3430 CAVPSDRGTQ 3440 LRWFKEGGQL 3450 PPGHSVQDGV 3460 LRIQNLDQSC 3470 QGTYICQAHG 3480 PWGKAQASAQ 3490 LVIQALPSVL 3500 INIRTSVQTV 3510 VVGHAVEFEC 3520 LALGDPKPQV 3530 TWSKVGGHLR 3540 PGIVQSGGVV 3550 RIAHVELADA 3560 GQYRCTATNA 3570 AGTTQSHVLL 3580 LVQALPQISM 3590 PQEVRVPAGS 3600 AAVFPCIASG 3610 YPTPDISWSK 3620 LDGSLPPDSR 3630 LENNMLMLPS 3640 VRPQDAGTYV 3650 CTATNRQGKV 3660 KAFAHLQVPE 3670 RVVPYFTQTP 3680 YSFLPLPTIK 3690 DAYRKFEIKI 3700 TFRPDSADGM 3710 LLYNGQKRVP 3720 GSPTNLANRQ 3730 PDFISFGLVG 3740 GRPEFRFDAG 3750 SGMATIRHPT 3760 PLALGHFHTV 3770 TLLRSLTQGS 3780 LIVGDLAPVN 3790 GTSQGKFQGL 3800 DLNEELYLGG 3810 YPDYGAIPKA 3820 GLSSGFIGCV 3830 RELRIQGEEI 3840 VFHDLNLTAH 3850 GISHCPTCRD 3860 RPCQNGGQCH 3870 DSESSSYVCV 3880 CPAGFTGSRC 3890 EHSQALHCHP 3900 EACGPDATCV 3910 NRPDGRGYTC 3920 RCHLGRSGLR 3930 CEEGVTVTTP 3940 SLSGAGSYLA 3950 LPALTNTHHE 3960 LRLDVEFKPL 3970 APDGVLLFSG 3980 GKSGPVEDFV 3990 SLAMVGGHLE 4000 FRYELGSGLA 4010 VLRSAEPLAL 4020 GRWHRVSAER 4030 LNKDGSLRVN 4040 GGRPVLRSSP 4050 GKSQGLNLHT 4060 LLYLGGVEPS 4070 VPLSPATNMS 4080 AHFRGCVGEV 4090 SVNGKRLDLT 4100 YSFLGSQGIG 4110 QCYDSSPCER 4120 QPCQHGATCM 4130 PAGEYEFQCL 4140 CRDGFKGDLC 4150 EHEENPCQLR 4160 EPCLHGGTCQ 4170 GTRCLCLPGF 4180 SGPRCQQGSG 4190 HGIAESDWHL 4200 EGSGGNDAPG 4210 QYGAYFHDDG 4220 FLAFPGHVFS 4230 RSLPEVPETI 4240 ELEVRTSTAS 4250 GLLLWQGVEV 4260 GEAGQGKDFI 4270 SLGLQDGHLV 4280 FRYQLGSGEA 4290 RLVSEDPIND 4300 GEWHRVTALR 4310 EGRRGSIQVD 4320 GEELVSGRSP 4330 GPNVAVNAKG 4340 SVYIGGAPDV 4350 ATLTGGRFSS 4360 GITGCVKNLV 4370 LHSARPGAPP 4380 PQPLDLQHRA 4390 QAGANTRPCP S

Gene Ontology

Classification GO ID Description
Molecular Function GO:0001540 amyloid-beta binding
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0071953 elastic fiber
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0140148 gel phase of basement membrane
Cellular Component GO:0005796 Golgi lumen
Cellular Component GO:0043202 lysosomal lumen
Cellular Component GO:0001527 microfibril
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098797 plasma membrane protein complex
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030021 extracellular matrix structural constituent conferring compression resistance
Molecular Function GO:0050750 low-density lipoprotein particle receptor binding
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007420 brain development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0072359 circulatory system development
Biological Process GO:0006954 inflammatory response
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0032223 negative regulation of synaptic transmission, cholinergic
Biological Process GO:0035418 protein localization to synapse
Biological Process GO:0006898 receptor-mediated endocytosis

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.