Search Results
Overview
| Uniprot ID | P98171 |
|---|---|
| Protein Name | Rho GTPase-activating protein 4 |
| Gene Name | ARHGAP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MAAHGKLRRERGL |
Function
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells
Protein Sequence
10
MAAHGKLRRE
20
RGLQAEYETQ
30
VKEMRWQLSE
40
QLRCLELQGE
50
LRRELLQELA
60
EFMRRRAEVE
70
LEYSRGLEKL
80
AERFSSRGGR
90
LGSSREHQSF
100
RKEPSLLSPL
110
HCWAVLLQHT
120
RQQSRESAAL
130
SEVLAGPLAQ
140
RLSHIAEDVG
150
RLVKKSRDLE
160
QQLQDELLEV
170
VSELQTAKKT
180
YQAYHMESVN
190
AEAKLREAER
200
QEEKRAGRSV
210
PTTTAGATEA
220
GPLRKSSLKK
230
GGRLVEKRQA
240
KFMEHKLKCT
250
KARNEYLLSL
260
ASVNAAVSNY
270
YLHDVLDLMD
280
CCDTGFHLAL
290
GQVLRSYTAA
300
ESRTQASQVQ
310
GLGSLEEAVE
320
ALDPPGDKAK
330
VLEVHATVFC
340
PPLRFDYHPH
350
DGDEVAEICV
360
EMELRDEILP
370
RAQNIQSRLD
380
RQTIETEEVN
390
KTLKATLQAL
400
LEVVASDDGD
410
VLDSFQTSPS
420
TESLKSTSSD
430
PGSRQAGRRR
440
GQQQETETFY
450
LTKLQEYLSG
460
RSILAKLQAK
470
HEKLQEALQR
480
GDKEEQEVSW
490
TQYTQRKFQK
500
SRQPRPSSQY
510
NQRLFGGDME
520
KFIQSSGQPV
530
PLVVESCIRF
540
INLNGLQHEG
550
IFRVSGAQLR
560
VSEIRDAFER
570
GEDPLVEGCT
580
AHDLDSVAGV
590
LKLYFRSLEP
600
PLFPPDLFGE
610
LLASSELEAT
620
AERVEHVSRL
630
LWRLPAPVLV
640
VLRYLFTFLN
650
HLAQYSDENM
660
MDPYNLAVCF
670
GPTLLPVPAG
680
QDPVALQGRV
690
NQLVQTLIVQ
700
PDRVFPPLTS
710
LPGPVYEKCM
720
APPSASCLGD
730
AQLESLGADN
740
EPELEAEMPA
750
QEDDLEGVVE
760
AVACFAYTGR
770
TAQELSFRRG
780
DVLRLHERAS
790
SDWWRGEHNG
800
MRGLIPHKYI
810
TLPAGTEKQV
820
VGAGLQTAGE
830
SGSSPEGLLA
840
SELVHRPEPC
850
TSPEAMGPSG
860
HRRRCLVPAS
870
PEQHVEVDKA
880
VAQNMDSVFK
890
ELLGKTSVRQ
900
GLGPASTTSP
910
SPGPRSPKAP
920
PSSRLGRNKG
930
FSRGPGAPAS
940
PSASHPQGLD
TTPKPH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0030517 | negative regulation of axon extension |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0010764 | negative regulation of fibroblast migration |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0051963 | regulation of synapse assembly |
| Biological Process | GO:0007266 | Rho protein signal transduction |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.