Search Results

Overview

Uniprot IDP98175
Protein NameRNA-binding protein 10
Gene NameRBM10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
246 PKSEAEQKLPLGTRL
337 NVRVIKDKQTQLNRG
464 HGYLKGTKGPGITGT
634 KETGAPSKEGKEKKE
637 GAPSKEGKEKKEKHK
646 KKEKHKTKTAQQIAK
653 KTAQQIAKDMERWAR
664 RWARSLNKQKENFKN
699 AGYAILEKKGALAER
700 GYAILEKKGALAERQ
824 RAAERREKYGIPEPP
834 IPEPPEPKRRKYGGI
837 PPEPKRRKYGGISTA
872 MLQAMGWKEGSGLGR
881 GSGLGRKKQGIVTPI
915 VTSTESYKETLHKTM
920 SYKETLHKTMVTRFN

Function

Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233)

Protein Sequence

10 MEYERRGGRG 20 DRTGRYGATD 30 RSQDDGGENR 40 SRDHDYRDMD 50 YRSYPREYGS 60 QEGKHDYDDS 70 SEEQSAEDSY 80 EASPGSETQR 90 RRRRRHRHSP 100 TGPPGFPRDG 110 DYRDQDYRTE 120 QGEEEEEEED 130 EEEEEKASNI 140 VMLRMLPQAA 150 TEDDIRGQLQ 160 SHGVQAREVR 170 LMRNKSSGQS 180 RGFAFVEFSH 190 LQDATRWMEA 200 NQHSLNILGQ 210 KVSMHYSDPK 220 PKINEDWLCN 230 KCGVQNFKRR 240 EKCFKCGVPK 250 SEAEQKLPLG 260 TRLDQQTLPL 270 GGRELSQGLL 280 PLPQPYQAQG 290 VLASQALSQG 300 SEPSSENAND 310 TIILRNLNPH 320 STMDSILGAL 330 APYAVLSSSN 340 VRVIKDKQTQ 350 LNRGFAFIQL 360 STIVEAAQLL 370 QILQALHPPL 380 TIDGKTINVE 390 FAKGSKRDMA 400 SNEGSRISAA 410 SVASTAIAAA 420 QWAISQASQG 430 GEGTWATSEE 440 PPVDYSYYQQ 450 DEGYGNSQGT 460 ESSLYAHGYL 470 KGTKGPGITG 480 TKGDPTGAGP 490 EASLEPGADS 500 VSMQAFSRAQ 510 PGAAPGIYQQ 520 SAEASSSQGT 530 AANSQSYTIM 540 SPAVLKSELQ 550 SPTHPSSALP 560 PATSPTAQES 570 YSQYPVPDVS 580 TYQYDETSGY 590 YYDPQTGLYY 600 DPNSQYYYNA 610 QSQQYLYWDG 620 ERRTYVPALE 630 QSADGHKETG 640 APSKEGKEKK 650 EKHKTKTAQQ 660 IAKDMERWAR 670 SLNKQKENFK 680 NSFQPISSLR 690 DDERRESATA 700 DAGYAILEKK 710 GALAERQHTS 720 MDLPKLASDD 730 RPSPPRGLVA 740 AYSGESDSEE 750 EQERGGPERE 760 EKLTDWQKLA 770 CLLCRRQFPS 780 KEALIRHQQL 790 SGLHKQNLEI 800 HRRAHLSENE 810 LEALEKNDME 820 QMKYRDRAAE 830 RREKYGIPEP 840 PEPKRRKYGG 850 ISTASVDFEQ 860 PTRDGLGSDN 870 IGSRMLQAMG 880 WKEGSGLGRK 890 KQGIVTPIEA 900 QTRVRGSGLG 910 ARGSSYGVTS 920 TESYKETLHK 930 TMVTRFNEAQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0035198 miRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.