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Overview

Uniprot IDP98198
Protein NamePhospholipid-transporting ATPase ID
Gene NameATP8B2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
54 QYASNCIKTSKYNIL

Function

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry

Protein Sequence

10 MTVPKEMPEK 20 WARAQAPPSW 30 SRKKPSWGTE 40 EERRARANDR 50 EYNEKFQYAS 60 NCIKTSKYNI 70 LTFLPVNLFE 80 QFQEVANTYF 90 LFLLILQLIP 100 QISSLSWFTT 110 IVPLVLVLTI 120 TAVKDATDDY 130 FRHKSDNQVN 140 NRQSQVLING 150 ILQQEQWMNV 160 CVGDIIKLEN 170 NQFVAADLLL 180 LSSSEPHGLC 190 YIETAELDGE 200 TNMKVRQAIP 210 VTSELGDISK 220 LAKFDGEVIC 230 EPPNNKLDKF 240 SGTLYWKENK 250 FPLSNQNMLL 260 RGCVLRNTEW 270 CFGLVIFAGP 280 DTKLMQNSGR 290 TKFKRTSIDR 300 LMNTLVLWIF 310 GFLVCMGVIL 320 AIGNAIWEHE 330 VGMRFQVYLP 340 WDEAVDSAFF 350 SGFLSFWSYI 360 IILNTVVPIS 370 LYVSVEVIRL 380 GHSYFINWDK 390 KMFCMKKRTP 400 AEARTTTLNE 410 ELGQVEYIFS 420 DKTGTLTQNI 430 MVFNKCSING 440 HSYGDVFDVL 450 GHKAELGERP 460 EPVDFSFNPL 470 ADKKFLFWDP 480 SLLEAVKIGD 490 PHTHEFFRLL 500 SLCHTVMSEE 510 KNEGELYYKA 520 QSPDEGALVT 530 AARNFGFVFR 540 SRTPKTITVH 550 EMGTAITYQL 560 LAILDFNNIR 570 KRMSVIVRNP 580 EGKIRLYCKG 590 ADTILLDRLH 600 HSTQELLNTT 610 MDHLNEYAGE 620 GLRTLVLAYK 630 DLDEEYYEEW 640 AERRLQASLA 650 QDSREDRLAS 660 IYEEVENNMM 670 LLGATAIEDK 680 LQQGVPETIA 690 LLTLANIKIW 700 VLTGDKQETA 710 VNIGYSCKML 720 TDDMTEVFIV 730 TGHTVLEVRE 740 ELRKAREKMM 750 DSSRSVGNGF 760 TYQDKLSSSK 770 LTSVLEAVAG 780 EYALVINGHS 790 LAHALEADME 800 LEFLETACAC 810 KAVICCRVTP 820 LQKAQVVELV 830 KKYKKAVTLA 840 IGDGANDVSM 850 IKTAHIGVGI 860 SGQEGIQAVL 870 ASDYSFSQFK 880 FLQRLLLVHG 890 RWSYLRMCKF 900 LCYFFYKNFA 910 FTMVHFWFGF 920 FCGFSAQTVY 930 DQYFITLYNI 940 VYTSLPVLAM 950 GVFDQDVPEQ 960 RSMEYPKLYE 970 PGQLNLLFNK 980 REFFICIAQG 990 IYTSVLMFFI 1000 PYGVFADATR 1010 DDGTQLADYQ 1020 SFAVTVATSL 1030 VIVVSVQIGL 1040 DTGYWTAINH 1050 FFIWGSLAVY 1060 FAILFAMHSN 1070 GLFDMFPNQF 1080 RFVGNAQNTL 1090 AQPTVWLTIV 1100 LTTVVCIMPV 1110 VAFRFLRLNL 1120 KPDLSDTVRY 1130 TQLVRKKQKA 1140 QHRCMRRVGR 1150 TGSRRSGYAF 1160 SHQEGFGELI 1170 MSGKNMRLSS 1180 LALSSFTTRS 1190 SSSWIESLRR 1200 KKSDSASSPS GGADKPLKG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:1990531 phospholipid-translocating ATPase complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140326 ATPase-coupled intramembrane lipid transporter activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0140345 phosphatidylcholine flippase activity
Molecular Function GO:0090554 phosphatidylcholine floppase activity
Biological Process GO:0007030 Golgi organization
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0045332 phospholipid translocation

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.