Search Results
Overview
| Uniprot ID | P99029 |
|---|---|
| Protein Name | Peroxiredoxin-5, mitochondrial |
| Gene Name | Prdx5 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | VEQAGALKAKGAQVV |
| 70 | VFEGEPGKKVNLAEL |
| 71 | FEGEPGKKVNLAELF |
| 79 | VNLAELFKGKKGVLF |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events
Protein Sequence
10
MLQLGLRVLG
20
CKASSVLRAS
30
TCLAGRAGRK
40
EAGWECGGAR
50
SFSSSAVTMA
60
PIKVGDAIPS
70
VEVFEGEPGK
80
KVNLAELFKG
90
KKGVLFGVPG
100
AFTPGCSKTH
110
LPGFVEQAGA
120
LKAKGAQVVA
130
CLSVNDVFVI
140
EEWGRAHQAE
150
GKVRLLADPT
160
GAFGKATDLL
170
LDDSLVSLFG
180
NRRLKRFSMV
190
IDNGIVKALN
200
VEPDGTGLTC
210
SLAPNILSQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0016209 | antioxidant activity |
| Molecular Function | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004601 | peroxidase activity |
| Molecular Function | GO:0072541 | peroxynitrite reductase activity |
| Molecular Function | GO:0001016 | RNA polymerase III transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Molecular Function | GO:0140824 | thioredoxin-dependent peroxiredoxin activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0051354 | negative regulation of oxidoreductase activity |
| Biological Process | GO:0016480 | negative regulation of transcription by RNA polymerase III |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:2001057 | reactive nitrogen species metabolic process |
| Biological Process | GO:0060785 | regulation of apoptosis involved in tissue homeostasis |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.