Search Results
Overview
| Uniprot ID | Q00266 |
|---|---|
| Protein Name | S-adenosylmethionine synthase isoform type-1 |
| Gene Name | MAT1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 223 | EEMRRALKEQVIRAV |
| 234 | IRAVVPAKYLDEDTV |
| 265 | DAGVTGRKIIVDTYG |
| 285 | GGGAFSGKDYTKVDR |
| 351 | ELLDVVHKNFDLRPG |
| 367 | IVRDLDLKKPIYQKT |
| 373 | LKKPIYQKTACYGHF |
| 53 | LKQDPNAKVACETVC |
| 88 | RVVRDTIKHIGYDDS |
| 97 | IGYDDSAKGFDFKTC |
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate
Protein Sequence
10
MNGPVDGLCD
20
HSLSEGVFMF
30
TSESVGEGHP
40
DKICDQISDA
50
VLDAHLKQDP
60
NAKVACETVC
70
KTGMVLLCGE
80
ITSMAMVDYQ
90
RVVRDTIKHI
100
GYDDSAKGFD
110
FKTCNVLVAL
120
EQQSPDIAQC
130
VHLDRNEEDV
140
GAGDQGLMFG
150
YATDETEECM
160
PLTIILAHKL
170
NARMADLRRS
180
GLLPWLRPDS
190
KTQVTVQYMQ
200
DNGAVIPVRI
210
HTIVISVQHN
220
EDITLEEMRR
230
ALKEQVIRAV
240
VPAKYLDEDT
250
VYHLQPSGRF
260
VIGGPQGDAG
270
VTGRKIIVDT
280
YGGWGAHGGG
290
AFSGKDYTKV
300
DRSAAYAARW
310
VAKSLVKAGL
320
CRRVLVQVSY
330
AIGVAEPLSI
340
SIFTYGTSQK
350
TERELLDVVH
360
KNFDLRPGVI
370
VRDLDLKKPI
380
YQKTACYGHF
390
GRSEFPWEVP
RKLVF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0048269 | methionine adenosyltransferase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004478 | methionine adenosyltransferase activity |
| Biological Process | GO:0009087 | L-methionine catabolic process |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0006556 | S-adenosylmethionine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.