Search Results

Overview

Uniprot IDQ00325
Protein NameSolute carrier family 25 member 3
Gene NameSLC25A3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 QVDPQKYKGIFNGFS
112 NGFSVTLKEDGVRGL
206 TLRDAAPKMYKEEGL
209 DAAPKMYKEEGLKAF
214 MYKEEGLKAFYKGVA
218 EGLKAFYKGVAPLWM
247 RTVEALYKFVVPKPR
295 VSVLNKEKGSSASLV
304 SSASLVLKRLGFKGV
313 LGFKGVWKGLFARII
99 RMQVDPQKYKGIFNG

Function

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)

Protein Sequence

10 MFSSVAHLAR 20 ANPFNTPHLQ 30 LVHDGLGDLR 40 SSSPGPTGQP 50 RRPRNLAAAA 60 VEEQYSCDYG 70 SGRFFILCGL 80 GGIISCGTTH 90 TALVPLDLVK 100 CRMQVDPQKY 110 KGIFNGFSVT 120 LKEDGVRGLA 130 KGWAPTFLGY 140 SMQGLCKFGF 150 YEVFKVLYSN 160 MLGEENTYLW 170 RTSLYLAASA 180 SAEFFADIAL 190 APMEAAKVRI 200 QTQPGYANTL 210 RDAAPKMYKE 220 EGLKAFYKGV 230 APLWMRQIPY 240 TMMKFACFER 250 TVEALYKFVV 260 PKPRSECSKP 270 EQLVVTFVAG 280 YIAGVFCAIV 290 SHPADSVVSV 300 LNKEKGSSAS 310 LVLKRLGFKG 320 VWKGLFARII 330 MIGTLTALQW 340 FIYDSVKVYF 350 RLPRPPPPEM 360 PESLKKKLGL TQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005315 phosphate transmembrane transporter activity
Molecular Function GO:0015317 phosphate:proton symporter activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:1990547 mitochondrial phosphate ion transmembrane transport
Biological Process GO:0035435 phosphate ion transmembrane transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.