Search Results

Overview

Uniprot IDQ00341
Protein NameVigilin
Gene NameHDLBP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1031 AANLDRAKAGLLERV
1039 AGLLERVKELQAEQE
1062 LSVTVDPKYHPKIIG
1071 HPKIIGRKGAVITQI
453 FHRHLIGKSGANINR
494 PQGVQQAKRELLELA
526 HRTIIGQKGERIREI
594 PIFKQFHKNIIGKGG
599 FHKNIIGKGGANIKK
632 ETIIITGKRANCEAA
672 HNSLIGTKGRLIRSI
711 GPSSDVEKAKKQLLH
714 SDVEKAKKQLLHLAE
72 GNKIRPIKASVITQV
723 LLHLAEEKQTKSFTV
745 YHKFLIGKGGGKIRK
860 KDCVEAAKKRIQEII
991 HRYVIGQKGSGIRKM

Function

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol

Protein Sequence

10 MSSVAVLTQE 20 SFAEHRSGLV 30 PQQIKVATLN 40 SEEESDPPTY 50 KDAFPPLPEK 60 AACLESAQEP 70 AGAWGNKIRP 80 IKASVITQVF 90 HVPLEERKYK 100 DMNQFGEGEQ 110 AKICLEIMQR 120 TGAHLELSLA 130 KDQGLSIMVS 140 GKLDAVMKAR 150 KDIVARLQTQ 160 ASATVAIPKE 170 HHRFVIGKNG 180 EKLQDLELKT 190 ATKIQIPRPD 200 DPSNQIKITG 210 TKEGIEKARH 220 EVLLISAEQD 230 KRAVERLEVE 240 KAFHPFIAGP 250 YNRLVGEIMQ 260 ETGTRINIPP 270 PSVNRTEIVF 280 TGEKEQLAQA 290 VARIKKIYEE 300 KKKKTTTIAV 310 EVKKSQHKYV 320 IGPKGNSLQE 330 ILERTGVSVE 340 IPPSDSISET 350 VILRGEPEKL 360 GQALTEVYAK 370 ANSFTVSSVA 380 APSWLHRFII 390 GKKGQNLAKI 400 TQQMPKVHIE 410 FTEGEDKITL 420 EGPTEDVNVA 430 QEQIEGMVKD 440 LINRMDYVEI 450 NIDHKFHRHL 460 IGKSGANINR 470 IKDQYKVSVR 480 IPPDSEKSNL 490 IRIEGDPQGV 500 QQAKRELLEL 510 ASRMENERTK 520 DLIIEQRFHR 530 TIIGQKGERI 540 REIRDKFPEV 550 IINFPDPAQK 560 SDIVQLRGPK 570 NEVEKCTKYM 580 QKMVADLVEN 590 SYSISVPIFK 600 QFHKNIIGKG 610 GANIKKIREE 620 SNTKIDLPAE 630 NSNSETIIIT 640 GKRANCEAAR 650 SRILSIQKDL 660 ANIAEVEVSI 670 PAKLHNSLIG 680 TKGRLIRSIM 690 EECGGVHIHF 700 PVEGSGSDTV 710 VIRGPSSDVE 720 KAKKQLLHLA 730 EEKQTKSFTV 740 DIRAKPEYHK 750 FLIGKGGGKI 760 RKVRDSTGAR 770 VIFPAAEDKD 780 QDLITIIGKE 790 DAVREAQKEL 800 EALIQNLDNV 810 VEDSMLVDPK 820 HHRHFVIRRG 830 QVLREIAEEY 840 GGVMVSFPRS 850 GTQSDKVTLK 860 GAKDCVEAAK 870 KRIQEIIEDL 880 EAQVTLECAI 890 PQKFHRSVMG 900 PKGSRIQQIT 910 RDFSVQIKFP 920 DREENAVHST 930 EPVVQENGDE 940 AGEGREAKDC 950 DPGSPRRCDI 960 IIISGRKEKC 970 EAAKEALEAL 980 VPVTIEVEVP 990 FDLHRYVIGQ 1000 KGSGIRKMMD 1010 EFEVNIHVPA 1020 PELQSDIIAI 1030 TGLAANLDRA 1040 KAGLLERVKE 1050 LQAEQEDRAL 1060 RSFKLSVTVD 1070 PKYHPKIIGR 1080 KGAVITQIRL 1090 EHDVNIQFPD 1100 KDDGNQPQDQ 1110 ITITGYEKNT 1120 EAARDAILRI 1130 VGELEQMVSE 1140 DVPLDHRVHA 1150 RIIGARGKAI 1160 RKIMDEFKVD 1170 IRFPQSGAPD 1180 PNCVTVTGLP 1190 ENVEEAIDHI 1200 LNLEEEYLAD 1210 VVDSEALQVY 1220 MKPPAHEEAK 1230 APSRGFVVRD 1240 APWTASSSEK 1250 APDMSSSEEF 1260 PSFGAQVAPK TLPWGPKR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0034364 high-density lipoprotein particle
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006869 lipid transport

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.