Search Results
Overview
| Uniprot ID | Q00577 |
|---|---|
| Protein Name | Transcriptional activator protein Pur-alpha |
| Gene Name | PURA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | DEPRRALKSEFLVRE |
| 250 | FMRVSEVKPTYRNSI |
| 71 | KRVDIQNKRFYLDVK |
| 87 | NAKGRFLKIAEVGAG |
| 97 | EVGAGGNKSRLTLSM |
Function
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097, PubMed:20976240). May play a role in the initiation of DNA replication and in recombination
Protein Sequence
10
MADRDSGSEQ
20
GGAALGSGGS
30
LGHPGSGSGS
40
GGGGGGGGGG
50
GGSGGGGGGA
60
PGGLQHETQE
70
LASKRVDIQN
80
KRFYLDVKQN
90
AKGRFLKIAE
100
VGAGGNKSRL
110
TLSMSVAVEF
120
RDYLGDFIEH
130
YAQLGPSQPP
140
DLAQAQDEPR
150
RALKSEFLVR
160
ENRKYYMDLK
170
ENQRGRFLRI
180
RQTVNRGPGL
190
GSTQGQTIAL
200
PAQGLIEFRD
210
ALAKLIDDYG
220
VEEEPAELPE
230
GTSLTVDNKR
240
FFFDVGSNKY
250
GVFMRVSEVK
260
PTYRNSITVP
270
YKVWAKFGHT
280
FCKYSEEMKK
290
IQEKQREKRA
300
ACEQLHQQQQ
310
QQQEETAAAT
320
LLLQGEEEGE
ED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0003691 | double-stranded telomeric DNA binding |
| Molecular Function | GO:0000900 | mRNA regulatory element binding translation repressor activity |
| Molecular Function | GO:0032422 | purine-rich negative regulatory element binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0046332 | SMAD binding |
| Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
| Biological Process | GO:0098963 | dendritic transport of messenger ribonucleoprotein complex |
| Biological Process | GO:0006270 | DNA replication initiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.