Overview
| Uniprot ID | Q00604 |
|---|
| Protein Name | Norrin |
|---|
| Gene Name | NDP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 86 |
VSFSTVLKQPFRSSC |
Function
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction
Protein Sequence
10
MRKHVLAASF
20
SMLSLLVIMG
30
DTDSKTDSSF
40
IMDSDPRRCM
50
RHHYVDSISH
60
PLYKCSSKMV
70
LLARCEGHCS
80
QASRSEPLVS
90
FSTVLKQPFR
100
SSCHCCRPQT
110
SKLKALRLRC
120
SGGMRLTATY
130
RYILSCHCEE
CNS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0005109 |
frizzled binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0046697 |
decidualization |
| Biological Process |
GO:0035426 |
extracellular matrix-cell signaling |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0110135 |
Norrin signaling pathway |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0007033 |
vacuole organization |
| Biological Process |
GO:0007601 |
visual perception |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.