Search Results

Overview

Uniprot IDQ00610
Protein NameClathrin heavy chain 1
Gene NameCLTC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1118 LAKAQLQKGMVKEAI
1254 ANSTRTWKEVCFACV
1441 RAVNYFSKVKQLPLV
1443 VNYFSKVKQLPLVKP
1501 SLAQRLEKHELIEFR
1516 RIAAYLFKGNNRWKQ
1522 FKGNNRWKQSVELCK
1529 KQSVELCKKDSLYKD
1530 QSVELCKKDSLYKDA
1609 VMKEYLTKVDKLDAS
1612 EYLTKVDKLDASESL
189 QLYSVDRKVSQPIEG
227 VRGQAGGKLHIIEVG
245 TGNQPFPKKAVDVFF
246 GNQPFPKKAVDVFFP
367 AEELFARKFNALFAQ
389 KVAANAPKGILRTPD
450 GRKQLLEKWLKEDKL
456 EKWLKEDKLECSEEL
506 QKIVLYAKKVGYTPD
507 KIVLYAKKVGYTPDW
619 HIAQLCEKAGLLQRA
637 FTDLYDIKRAVVHTH
737 KYIQAACKTGQIKEV
742 ACKTGQIKEVERICR
798 LYRNNLQKYIEIYVQ
806 YIEIYVQKVNPSRLP
851 ELVAEVEKRNRLKLL
856 VEKRNRLKLLLPWLE
96 QIFNIEMKSKMKAHT

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)

Protein Sequence

10 MAQILPIRFQ 20 EHLQLQNLGI 30 NPANIGFSTL 40 TMESDKFICI 50 REKVGEQAQV 60 VIIDMNDPSN 70 PIRRPISADS 80 AIMNPASKVI 90 ALKAGKTLQI 100 FNIEMKSKMK 110 AHTMTDDVTF 120 WKWISLNTVA 130 LVTDNAVYHW 140 SMEGESQPVK 150 MFDRHSSLAG 160 CQIINYRTDA 170 KQKWLLLTGI 180 SAQQNRVVGA 190 MQLYSVDRKV 200 SQPIEGHAAS 210 FAQFKMEGNA 220 EESTLFCFAV 230 RGQAGGKLHI 240 IEVGTPPTGN 250 QPFPKKAVDV 260 FFPPEAQNDF 270 PVAMQISEKH 280 DVVFLITKYG 290 YIHLYDLETG 300 TCIYMNRISG 310 ETIFVTAPHE 320 ATAGIIGVNR 330 KGQVLSVCVE 340 EENIIPYITN 350 VLQNPDLALR 360 MAVRNNLAGA 370 EELFARKFNA 380 LFAQGNYSEA 390 AKVAANAPKG 400 ILRTPDTIRR 410 FQSVPAQPGQ 420 TSPLLQYFGI 430 LLDQGQLNKY 440 ESLELCRPVL 450 QQGRKQLLEK 460 WLKEDKLECS 470 EELGDLVKSV 480 DPTLALSVYL 490 RANVPNKVIQ 500 CFAETGQVQK 510 IVLYAKKVGY 520 TPDWIFLLRN 530 VMRISPDQGQ 540 QFAQMLVQDE 550 EPLADITQIV 560 DVFMEYNLIQ 570 QCTAFLLDAL 580 KNNRPSEGPL 590 QTRLLEMNLM 600 HAPQVADAIL 610 GNQMFTHYDR 620 AHIAQLCEKA 630 GLLQRALEHF 640 TDLYDIKRAV 650 VHTHLLNPEW 660 LVNYFGSLSV 670 EDSLECLRAM 680 LSANIRQNLQ 690 ICVQVASKYH 700 EQLSTQSLIE 710 LFESFKSFEG 720 LFYFLGSIVN 730 FSQDPDVHFK 740 YIQAACKTGQ 750 IKEVERICRE 760 SNCYDPERVK 770 NFLKEAKLTD 780 QLPLIIVCDR 790 FDFVHDLVLY 800 LYRNNLQKYI 810 EIYVQKVNPS 820 RLPVVIGGLL 830 DVDCSEDVIK 840 NLILVVRGQF 850 STDELVAEVE 860 KRNRLKLLLP 870 WLEARIHEGC 880 EEPATHNALA 890 KIYIDSNNNP 900 ERFLRENPYY 910 DSRVVGKYCE 920 KRDPHLACVA 930 YERGQCDLEL 940 INVCNENSLF 950 KSLSRYLVRR 960 KDPELWGSVL 970 LESNPYRRPL 980 IDQVVQTALS 990 ETQDPEEVSV 1000 TVKAFMTADL 1010 PNELIELLEK 1020 IVLDNSVFSE 1030 HRNLQNLLIL 1040 TAIKADRTRV 1050 MEYINRLDNY 1060 DAPDIANIAI 1070 SNELFEEAFA 1080 IFRKFDVNTS 1090 AVQVLIEHIG 1100 NLDRAYEFAE 1110 RCNEPAVWSQ 1120 LAKAQLQKGM 1130 VKEAIDSYIK 1140 ADDPSSYMEV 1150 VQAANTSGNW 1160 EELVKYLQMA 1170 RKKARESYVE 1180 TELIFALAKT 1190 NRLAELEEFI 1200 NGPNNAHIQQ 1210 VGDRCYDEKM 1220 YDAAKLLYNN 1230 VSNFGRLAST 1240 LVHLGEYQAA 1250 VDGARKANST 1260 RTWKEVCFAC 1270 VDGKEFRLAQ 1280 MCGLHIVVHA 1290 DELEELINYY 1300 QDRGYFEELI 1310 TMLEAALGLE 1320 RAHMGMFTEL 1330 AILYSKFKPQ 1340 KMREHLELFW 1350 SRVNIPKVLR 1360 AAEQAHLWAE 1370 LVFLYDKYEE 1380 YDNAIITMMN 1390 HPTDAWKEGQ 1400 FKDIITKVAN 1410 VELYYRAIQF 1420 YLEFKPLLLN 1430 DLLMVLSPRL 1440 DHTRAVNYFS 1450 KVKQLPLVKP 1460 YLRSVQNHNN 1470 KSVNESLNNL 1480 FITEEDYQAL 1490 RTSIDAYDNF 1500 DNISLAQRLE 1510 KHELIEFRRI 1520 AAYLFKGNNR 1530 WKQSVELCKK 1540 DSLYKDAMQY 1550 ASESKDTELA 1560 EELLQWFLQE 1570 EKRECFGACL 1580 FTCYDLLRPD 1590 VVLETAWRHN 1600 IMDFAMPYFI 1610 QVMKEYLTKV 1620 DKLDASESLR 1630 KEEEQATETQ 1640 PIVYGQPQLM 1650 LTAGPSVAVP 1660 PQAPFGYGYT 1670 APPYGQPQPG FGYSM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030118 clathrin coat
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0050750 low-density lipoprotein particle receptor binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005198 structural molecule activity
Molecular Function GO:1990381 ubiquitin-specific protease binding
Biological Process GO:0150093 amyloid-beta clearance by transcytosis
Biological Process GO:0006914 autophagy
Biological Process GO:0051301 cell division
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0072318 clathrin coat disassembly
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:1900126 negative regulation of hyaluronan biosynthetic process
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0033572 transferrin transport
Cellular Component GO:0030132 clathrin coat of coated pit
Cellular Component GO:0030130 clathrin coat of trans-Golgi network vesicle
Cellular Component GO:0071439 clathrin complex
Cellular Component GO:0045334 clathrin-coated endocytic vesicle
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0036020 endolysosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005764 lysosome
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:1990498 mitotic spindle microtubule
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0005819 spindle
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0032051 clathrin light chain binding
Molecular Function GO:0097718 disordered domain specific binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.