Search Results

Overview

Uniprot IDQ00688
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP3
Gene NameFKBP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 TLDEGPPKYTKSVLK
113 EGPPKYTKSVLKKGD
127 DKTNFPKKGDVVHCW
170 SFKVGVGKVIRGWDE
200 EPEWAYGKKGQPDAK
201 PEWAYGKKGQPDAKI
22 LRSEQLPKKDIIKFL
23 RSEQLPKKDIIKFLQ
48 HKLLGNIKNVAKTAN
56 NVAKTANKDHLVTAY
70 YNHLFETKRFKGTES
80 KGTESISKVSEQVKN
86 SKVSEQVKNVKLNED
89 SEQVKNVKLNEDKPK
96 KLNEDKPKETKSEET
99 EDKPKETKSEETLDE

Function

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins

Protein Sequence

10 MAAAVPQRAW 20 TVEQLRSEQL 30 PKKDIIKFLQ 40 EHGSDSFLAE 50 HKLLGNIKNV 60 AKTANKDHLV 70 TAYNHLFETK 80 RFKGTESISK 90 VSEQVKNVKL 100 NEDKPKETKS 110 EETLDEGPPK 120 YTKSVLKKGD 130 KTNFPKKGDV 140 VHCWYTGTLQ 150 DGTVFDTNIQ 160 TSAKKKKNAK 170 PLSFKVGVGK 180 VIRGWDEALL 190 TMSKGEKARL 200 EIEPEWAYGK 210 KGQPDAKIPP 220 NAKLTFEVEL VDID

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005528 FK506 binding
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0038023 signaling receptor activity

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.