Search Results

Overview

Uniprot ID	Q00765
Protein Name	Receptor expression-enhancing protein 5
Gene Name	REEP5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
16	FDRFLHEKNCMTDLL
164	KDLKDKAKETADAIT
172	ETADAITKEAKKATV
176	AITKEAKKATVNLLG
186	VNLLGEEKKST****
29	LLAKLEAKTGVNRSF

Function

Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes

Protein Sequence

10 MSAAMRERFD 20 RFLHEKNCMT 30 DLLAKLEAKT 40 GVNRSFIALG 50 VIGLVALYLV 60 FGYGASLLCN 70 LIGFGYPAYI 80 SIKAIESPNK 90 EDDTQWLTYW 100 VVYGVFSIAE 110 FFSDIFLSWF 120 PFYYMLKCGF 130 LLWCMAPSPS 140 NGAELLYKRI 150 IRPFFLKHES 160 QMDSVVKDLK 170 DKAKETADAI 180 TKEAKKATVN LLGEEKKST

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0071782	endoplasmic reticulum tubular network
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane
Biological Process	GO:0090158	endoplasmic reticulum membrane organization
Biological Process	GO:0007029	endoplasmic reticulum organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.