Search Results

Overview

Uniprot IDQ00796
Protein NameSorbitol dehydrogenase
Gene NameSORD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 RENDEFCKMGRYNLS
134 GNLCRFYKHNAAFCY
214 ATRLSKAKEIGADLV
295 AIREVDIKGVFRYCN
319 ASKSVNVKPLVTHRF
330 THRFPLEKALEAFET
339 LEAFETFKKGLGLKI
6 **MAAAAKPNNLSLV
63 RIGNFIVKKPMVLGH
64 IGNFIVKKPMVLGHE
78 EASGTVEKVGSSVKH
84 EKVGSSVKHLKPGDR
87 GSSVKHLKPGDRVAI

Function

Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:25105142, PubMed:29966615). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415)

Protein Sequence

10 MAAAAKPNNL 20 SLVVHGPGDL 30 RLENYPIPEP 40 GPNEVLLRMH 50 SVGICGSDVH 60 YWEYGRIGNF 70 IVKKPMVLGH 80 EASGTVEKVG 90 SSVKHLKPGD 100 RVAIEPGAPR 110 ENDEFCKMGR 120 YNLSPSIFFC 130 ATPPDDGNLC 140 RFYKHNAAFC 150 YKLPDNVTFE 160 EGALIEPLSV 170 GIHACRRGGV 180 TLGHKVLVCG 190 AGPIGMVTLL 200 VAKAMGAAQV 210 VVTDLSATRL 220 SKAKEIGADL 230 VLQISKESPQ 240 EIARKVEGQL 250 GCKPEVTIEC 260 TGAEASIQAG 270 IYATRSGGNL 280 VLVGLGSEMT 290 TVPLLHAAIR 300 EVDIKGVFRY 310 CNTWPVAISM 320 LASKSVNVKP 330 LVTHRFPLEK 340 ALEAFETFKK 350 GLGLKIMLKC DPSDQNP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016020 membrane
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0031514 motile cilium
Molecular Function GO:0000721 (R,R)-butanediol dehydrogenase activity
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0046526 D-xylulose reductase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0050255 ribitol 2-dehydrogenase (NAD+) activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0046370 fructose biosynthetic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006062 sorbitol catabolic process
Biological Process GO:0051160 xylitol catabolic process
Biological Process GO:0051164 xylitol metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.