Search Results

Overview

Uniprot IDQ007T5
Protein NameADP-ribosylation factor 6
Gene NameARF6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
7 *MGKVLSKIFGNKEM

Function

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity)

Protein Sequence

10 MGKVLSKIFG 20 NKEMRILMLG 30 LDAAGKTTIL 40 YKLKLGQSVT 50 TIPTVGFNVE 60 TVTYKNVKFN 70 VWDVGGQDKI 80 RPLWRHYYTG 90 TQGLIFVVDC 100 ADRDRIDEAR 110 QELHRIINDR 120 EMRDAIILIF 130 ANKQDLPDAM 140 KPHEIQEKLG 150 LTRIRDRNWY 160 VQPSCATSGD 170 GLYEGLTWLT SNYKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005768 endosome
Cellular Component GO:0031527 filopodium membrane
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0055038 recycling endosome membrane
Cellular Component GO:0001726 ruffle
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0035591 signaling adaptor activity
Molecular Function GO:0031996 thioesterase binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0032456 endocytic recycling
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:2000009 negative regulation of protein localization to cell surface
Biological Process GO:0007399 nervous system development
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0120183 positive regulation of focal adhesion disassembly
Biological Process GO:0051549 positive regulation of keratinocyte migration
Biological Process GO:1903438 positive regulation of mitotic cytokinetic process
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:1905345 protein localization to cleavage furrow
Biological Process GO:0036010 protein localization to endosome
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0060998 regulation of dendritic spine development
Biological Process GO:0051489 regulation of filopodium assembly
Biological Process GO:0035020 regulation of Rac protein signal transduction
Biological Process GO:0097178 ruffle assembly
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.