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Overview

Uniprot IDQ00900
Protein NameHuman immunodeficiency virus type I enhancer-binding protein 2 homolog
Gene NameHivep2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
497 VNMLKTTKFNSECRQ
616 EHPARVPKILAGSSL

Function

Binds to DNA at the acute-phase response element of the angiotensinogen gene and related nuclear factor kappa-B binding sites through a zinc-finger motif

Protein Sequence

10 MDTGDTALGQ 20 KATSRSGETD 30 SVSGRWRQEQ 40 SAGLKMSTFS 50 SQEGQRQPQI 60 DPDQIGNVAS 70 AQLFGSGKLA 80 SPGEGVHQVT 90 EKQYPPHRPS 100 PYPCQHSLSF 110 PQHSLPQGMM 120 HSNKPHQSLE 130 GPPWLFSGPL 140 PSVASEDLFP 150 FPMHGHSSGY 160 PRKKISSLNP 170 AYSQYSQKSI 180 EQAEDAHKKE 190 HKPKKPGKYI 200 CPYCSRACAK 210 PSVLKKHIRS 220 HTGERPYPCI 230 PCGFSFKTKS 240 NLYKHRKSHA 250 HAIKAGLVPF 260 TESSVSKLDL 270 EAGFIDVEAE 280 IHSDGEQSTD 290 TDEESSLFAE 300 ASDKVSPGPP 310 IPLDIASRGG 320 YPGSLEESLG 330 GPMKVPILII 340 PKSGIPLPNE 350 GSQYLGPDML 360 PNPSLNAKAD 370 DSHTVKQKLA 380 LRLSEKKGQD 390 SEPSLNLLSP 400 HSKGSTDSGY 410 FSRSESAEQQ 420 ISPPNTNAKS 430 YEEIIFGKYC 440 RLSPRNTLSV 450 TPTGQERTAM 460 GRRGLVEPLP 470 HVNTRLEVKM 480 FEDPITQLIP 490 SKGEMDPSQV 500 NMLKTTKFNS 510 ECRQPQAMAA 520 SVRNEGKPYP 530 GSFPGSNPIL 540 LEAPVDSSPL 550 IRSNSMPTSS 560 ATNLSIPPSL 570 RGSHSFDERM 580 TGSDDVFYPG 590 TVGIPPQRML 600 RRQAAFELPS 610 VQEGHMEFEH 620 PARVPKILAG 630 SSLKEKKLVP 640 GDRSGYDYDA 650 CRKPYKKWED 660 PETPKQSYRD 670 ISCLSTFKHG 680 GEYFMDPSVP 690 LPGVPTMFGT 700 TCENRKRRKE 710 KSVGDEEDTP 720 MICGGMGSAP 730 GSMMSSEYDS 740 KLQDGGRSGF 750 TMTGHESLPH 760 GYSDRLDLAR 770 PQLPSRSPSL 780 GSEDLPSAGD 790 PDKMTDLGKK 800 PPGNVISVIQ 810 HTNSLSRPNS 820 FERSESTEMA 830 VSTQDKTPSP 840 SEMGDSEVLE 850 GPVSPEWAPP 860 GDGAESGSRP 870 TPSQQVPQHS 880 YHGQPRLVRQ 890 HNIQVPEIRV 900 TEEPDKPEKE 910 KEAPTKEPEK 920 PVEEFQWPQR 930 SETLSQLPAE 940 KLPPKKKRLR 950 LADMEHSSGE 960 SSFESTGTGL 970 SRSPSQESNL 980 SHSSSFSMSF 990 DRDETVKLTA 1000 PPKQDESGKH 1010 SEFLTVPAGS 1020 YSLSVPGHHH 1030 QKEMRRCSSE 1040 QMPCPHPTEV 1050 PEIRSKSFDY 1060 GNLSHAPVAG 1070 ASPSTLSPSR 1080 ERKKCFLVRQ 1090 ASFSGSPEIA 1100 QGEAGMDPSV 1110 KQEQLEQLHA 1120 GLRAAWTTVL 1130 PPLPGDDPGK 1140 QVVGPCGQLS 1150 SGPPLHLAQQ 1160 QIMHMDSQES 1170 LRNPLIQPTS 1180 YMTGKHLPEQ 1190 PHLFPHQDAV 1200 PFSPIQNALF 1210 QFQYPTVCMV 1220 HLPAQQPPWW 1230 QAHFPHPFTP 1240 HPQNSYSKPP 1250 FQADIHSSYS 1260 LEHVAEHTGK 1270 KSADYPHAKE 1280 QTYPCYSGAS 1290 GLHSKNLPPK 1300 FPSDPGSKST 1310 EAPPTEQLLR 1320 EDFASENAGP 1330 LQSLPGTVVP 1340 VRIQTHVPSY 1350 GSVMYTSISQ 1360 ILGQNSPAIV 1370 ICKVDENMTQ 1380 RTLVTNAAMQ 1390 GIGFNIAQVL 1400 GQRTGLEKYP 1410 LWKVPQTLPL 1420 GLESSIPLCL 1430 PSTSDSAASL 1440 GGSKRMLSPA 1450 SSLELFMETK 1460 QQKRVKEEKM 1470 YGQIVEELSA 1480 VELTNSDIKK 1490 GLSRPQKPQL 1500 VRQGCASEPK 1510 DGSSQSRSSS 1520 FSSLSPSSSQ 1530 DHPAASGPFP 1540 PNREILSGSR 1550 APPRRKFSGP 1560 SESRESSDEL 1570 DIDETSSDMS 1580 MSPQSSSLPT 1590 GGSQQEDEGK 1600 ARKLPVSMLV 1610 HMASGPGGNV 1620 ANSTLLFTDV 1630 ADFQQILQFP 1640 SLRTTTTVSW 1650 CFLNYTKPNF 1660 VQQATFKSSV 1670 YASWCISSCN 1680 PNPSGLNTKT 1690 TLALLRSKQK 1700 ITAEIYTLAA 1710 MHRPGTGKLT 1720 SSSAWKQFAQ 1730 MKPDAPFLFG 1740 NKLERKLGGN 1750 VLKERGKGEI 1760 HGDKDLGSKQ 1770 TEPIRIKIFE 1780 GGYKSNEDYV 1790 YVRGRGRGKY 1800 ICEECGIRCK 1810 KPSMLKKHIR 1820 THTDVRPYVC 1830 KLCNFAFKTK 1840 GNLTKHMKSK 1850 AHMKKCLELG 1860 VSMTSVDETE 1870 TEEAENMEDL 1880 HKTSEKHSMS 1890 GISTDHQFSD 1900 AEESDGEDGD 1910 DNDEDDEDDD 1920 DFDDQGDLTP 1930 KTRSRSTSPQ 1940 PPRFSSLPVN 1950 VGAVAHGVPS 1960 DSSLGHSSLI 1970 SYLVTLPSIQ 1980 VTQLMTPSDS 1990 CEDTQMTEYQ 2000 RLFQSKSTDS 2010 EPDKDRLDIP 2020 SSMDEEAMLS 2030 SEPSSSPRDF 2040 SPSSYRSSPG 2050 YDSSPCRDNS 2060 PKRYLIPKGD 2070 LSPRRHLSPR 2080 RDLSPMRHLS 2090 PRKEAALRRE 2100 MSQGDASPRR 2110 HLSPRRPLSP 2120 GKDITTRRDL 2130 SPRRERRYMT 2140 TIRAPSPRRA 2150 LYHNPPLPMG 2160 QYLQTEPIVL 2170 GPPNLRRGLP 2180 QVPYFSLYGD 2190 QEGAYEHHGS 2200 SLFPEGPTDY 2210 VFSHLPLHSQ 2220 QQVRAPIPMV 2230 PVGGIQMVHS 2240 LPPAISGLHP 2250 PPTLPLPTEG 2260 SEEKKGAPGE 2270 ALTQDPYTLS 2280 RRHEKQAPHV 2290 LQSSGLPSSP 2300 SSPRLLMKQS 2310 TSEDSLNSTE 2320 REQEENIQTC 2330 TKAIASLRIA 2340 TEEAALLGAD 2350 QPTWVQESPQ 2360 KPLESAHISI 2370 RHFSGPEPGQ 2380 LCTSAAHPDL 2390 HDGEKDTFGT 2400 SQTAVAHPTF 2410 YSKGSVDEKQ 2420 VDFQSSKELS 2430 LSTEEGNEPS SEKNRLH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.