Search Results
Overview
| Uniprot ID | Q00978 |
|---|---|
| Protein Name | Interferon regulatory factor 9 |
| Gene Name | IRF9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | IPWKHAGKQDFREDQ |
Function
Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
Protein Sequence
10
MASGRARCTR
20
KLRNWVVEQV
30
ESGQFPGVCW
40
DDTAKTMFRI
50
PWKHAGKQDF
60
REDQDAAFFK
70
AWAIFKGKYK
80
EGDTGGPAVW
90
KTRLRCALNK
100
SSEFKEVPER
110
GRMDVAEPYK
120
VYQLLPPGIV
130
SGQPGTQKVP
140
SKRQHSSVSS
150
ERKEEEDAMQ
160
NCTLSPSVLQ
170
DSLNNEEEGA
180
SGGAVHSDIG
190
SSSSSSSPEP
200
QEVTDTTEAP
210
FQGDQRSLEF
220
LLPPEPDYSL
230
LLTFIYNGRV
240
VGEAQVQSLD
250
CRLVAEPSGS
260
ESSMEQVLFP
270
KPGPLEPTQR
280
LLSQLERGIL
290
VASNPRGLFV
300
QRLCPIPISW
310
NAPQAPPGPG
320
PHLLPSNECV
330
ELFRTAYFCR
340
DLVRYFQGLG
350
PPPKFQVTLN
360
FWEESHGSSH
370
TPQNLITVKM
380
EQAFARYLLE
390
QTPEQQAAIL
SLV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
PMID: N/A