Search Results
Overview
| Uniprot ID | Q00981 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| Gene Name | Uchl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | QFLSETEKLSPEDRA |
| 135 | DRAKCFEKNEAIQAA |
| 19 | MLNKVLAKLGVAGQW |
| 65 | QHENFRKKQIEELKG |
| 71 | KKQIEELKGQEVSPK |
| 78 | KGQEVSPKVYFMKQT |
Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (By similarity). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0031694 | alpha-2A adrenergic receptor binding |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008242 | omega peptidase activity |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0007628 | adult walking behavior |
| Biological Process | GO:0007412 | axon target recognition |
| Biological Process | GO:0019896 | axonal transport of mitochondrion |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0042755 | eating behavior |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0050905 | neuromuscular process |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.