Search Results
Overview
| Uniprot ID | Q01066 |
|---|---|
| Protein Name | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
| Gene Name | Pde1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 452 | PLTDDDSKSKSQPSF |
Function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate
Protein Sequence
10
MELSPRSPPE
20
MLESDCPSPL
30
ELKSAPSKKM
40
WIKLRSLLRY
50
MVKQLENGEV
60
NIEELKKNLE
70
YTASLLEAVY
80
IDETRQILDT
90
EDELRELRSD
100
AVPSEVRDWL
110
ASTFTQQTRA
120
KGRRAEEKPK
130
FRSIVHAVQA
140
GIFVERMFRR
150
TYTAVGPTYS
160
TAVHNCLKNL
170
DVWCFDVFSL
180
NRAADDHALR
190
TIVFELLTRH
200
SLISRFKIPT
210
VFLMSFLEAL
220
ETGYGKYKNP
230
YHNQIHAADV
240
TQTVHCFLLR
250
TGMVHCLSEI
260
EVLAIIFAAA
270
IHDYEHTGTT
280
NSFHIQTKSE
290
CAILYNDRSV
300
LENHHISSVF
310
RMMQDDEMNI
320
FINLTKDEFV
330
ELRALVIEMV
340
LATDMSCHFQ
350
QVKTMKTALQ
360
QLERIDKSKA
370
LSLLLHAADI
380
SHPTKQWSVH
390
SRWTKALMEE
400
FFRQGDKEAE
410
LGLPFSPLCD
420
RTSTLVAQSQ
430
IGFIDFIVEP
440
TFSVLTDVAE
450
KSVQPLTDDD
460
SKSKSQPSFQ
470
WRQPSLDVDV
480
GDPNPDVVSF
490
RSTWTKYIQE
500
NKQKWKERAA
510
SGITNQMSID
520
ELSPCEEEAP
530
SSPAEDEHNQ
NGNLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0036006 | cellular response to macrophage colony-stimulating factor stimulus |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity |
| Molecular Function | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0048101 | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity |
| Molecular Function | GO:0004117 | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity |
| Molecular Function | GO:0004112 | cyclic-nucleotide phosphodiesterase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0030224 | monocyte differentiation |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0042428 | serotonin metabolic process |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0008542 | visual learning |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.