Search Results
Overview
| Uniprot ID | Q01081 |
|---|---|
| Protein Name | Splicing factor U2AF 35 kDa subunit |
| Gene Name | U2AF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | ASIFGTEKDKVNCSF |
| 15 | IFGTEKDKVNCSFYF |
Function
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron
Protein Sequence
10
MAEYLASIFG
20
TEKDKVNCSF
30
YFKIGACRHG
40
DRCSRLHNKP
50
TFSQTIALLN
60
IYRNPQNSSQ
70
SADGLRCAVS
80
DVEMQEHYDE
90
FFEEVFTEME
100
EKYGEVEEMN
110
VCDNLGDHLV
120
GNVYVKFRRE
130
EDAEKAVIDL
140
NNRWFNGQPI
150
HAELSPVTDF
160
REACCRQYEM
170
GECTRGGFCN
180
FMHLKPISRE
190
LRRELYGRRR
200
KKHRSRSRSR
210
ERRSRSRDRG
220
RGGGGGGGGG
230
GGGRERDRRR
240
SRDRERSGRF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0089701 | U2AF complex |
| Molecular Function | GO:0030628 | pre-mRNA 3'-splice site binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0050733 | RS domain binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0008380 | RNA splicing |
Reference
PMID: N/A