Search Results

Overview

Uniprot IDQ01082
Protein NameSpectrin beta chain, non-erythrocytic 1
Gene NameSPTBN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1021 DLQKEAEKLESEHPD
1120 NYEEDYQKMRDMGEM
1210 GAEAAIKKQEDFMTT
124 DKALQFLKEQRVHLE
1249 NSDRIQEKVDSIDDR
1354 TEAVVKEKLTGLHKM
1360 EKLTGLHKMWEVLES
1420 TSVNILLKKQQMLEN
1421 SVNILLKKQQMLENQ
1451 QALSQEGKSTDEVDS
1478 LEPLNERKHNLLASK
1526 TVQLLIKKNQTLQKE
1622 MMSEEKAKDEQSAVS
1632 QSAVSMLKKHQILEQ
1633 SAVSMLKKHQILEQA
1653 ETVHQLSKTSRALVA
1678 MRQSKVDKLYAGLKD
1684 DKLYAGLKDLAEERR
173 TEDNKEKKSAKDALL
1809 AASYELHKFYHDAKE
1815 HKFYHDAKEIFGRIQ
1827 RIQDKHKKLPEELGR
1878 QAAYAGDKADDIQKR
1913 RLVDTGDKFRFFSMV
1981 GKSLLARKHYASEEI
1991 ASEEIKEKLLQLTEK
1998 KLLQLTEKRKEMIDK
2064 KRHEAFEKSAATWDE
2177 PTSDRKAKTALPAQS
2238 NQEMGFYKDAKTAAS
224 PDLIDFDKLKKSNAH
2241 MGFYKDAKTAASGIP
2269 CEVALDYKKKKHVFK
227 IDFDKLKKSNAHYNL
2270 EVALDYKKKKHVFKL
2344 TSESSPGKREKDKEK
2362 KRFSLFGKKK*****
2363 RFSLFGKKK******
288 KALAVEGKRIGKVLD
292 VEGKRIGKVLDNAIE
379 KMRANNQKVYMPREG
419 NELIRQEKLEQLARR
463 AVEAATKKHEAIETD
497 AENYHDIKRITARKD
62 VQKKTFTKWVNSHLA
659 GWIREKEKILSSDDY
668 LSSDDYGKDLTSVMR
784 YSTQSLVKKHKDVAE
842 AELTRLRKQALQDTL
976 SWIREKTKVIESTQD
997 GVMALQRKLTGMERD

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function

Protein Sequence

10 MTTTVATDYD 20 NIEIQQQYSD 30 VNNRWDVDDW 40 DNENSSARLF 50 ERSRIKALAD 60 EREAVQKKTF 70 TKWVNSHLAR 80 VSCRITDLYT 90 DLRDGRMLIK 100 LLEVLSGERL 110 PKPTKGRMRI 120 HCLENVDKAL 130 QFLKEQRVHL 140 ENMGSHDIVD 150 GNHRLTLGLI 160 WTIILRFQIQ 170 DISVETEDNK 180 EKKSAKDALL 190 LWCQMKTAGY 200 PNVNIHNFTT 210 SWRDGMAFNA 220 LIHKHRPDLI 230 DFDKLKKSNA 240 HYNLQNAFNL 250 AEQHLGLTKL 260 LDPEDISVDH 270 PDEKSIITYV 280 VTYYHYFSKM 290 KALAVEGKRI 300 GKVLDNAIET 310 EKMIEKYESL 320 ASDLLEWIEQ 330 TIIILNNRKF 340 ANSLVGVQQQ 350 LQAFNTYRTV 360 EKPPKFTEKG 370 NLEVLLFTIQ 380 SKMRANNQKV 390 YMPREGKLIS 400 DINKAWERLE 410 KAEHERELAL 420 RNELIRQEKL 430 EQLARRFDRK 440 AAMRETWLSE 450 NQRLVSQDNF 460 GFDLPAVEAA 470 TKKHEAIETD 480 IAAYEERVQA 490 VVAVARELEA 500 ENYHDIKRIT 510 ARKDNVIRLW 520 EYLLELLRAR 530 RQRLEMNLGL 540 QKIFQEMLYI 550 MDWMDEMKVL 560 VLSQDYGKHL 570 LGVEDLLQKH 580 TLVEADIGIQ 590 AERVRGVNAS 600 AQKFATDGEG 610 YKPCDPQVIR 620 DRVAHMEFCY 630 QELCQLAAER 640 RARLEESRRL 650 WKFFWEMAEE 660 EGWIREKEKI 670 LSSDDYGKDL 680 TSVMRLLSKH 690 RAFEDEMSGR 700 SGHFEQAIKE 710 GEDMIAEEHF 720 GSEKIRERII 730 YIREQWANLE 740 QLSAIRKKRL 750 EEASLLHQFQ 760 ADADDIDAWM 770 LDILKIVSSS 780 DVGHDEYSTQ 790 SLVKKHKDVA 800 EEIANYRPTL 810 DTLHEQASAL 820 PQEHAESPDV 830 RGRLSGIEER 840 YKEVAELTRL 850 RKQALQDTLA 860 LYKMFSEADA 870 CELWIDEKEQ 880 WLNNMQIPEK 890 LEDLEVIQHR 900 FESLEPEMNN 910 QASRVAVVNQ 920 IARQLMHSGH 930 PSEKEIKAQQ 940 DKLNTRWSQF 950 RELVDRKKDA 960 LLSALSIQNY 970 HLECNETKSW 980 IREKTKVIES 990 TQDLGNDLAG 1000 VMALQRKLTG 1010 MERDLVAIEA 1020 KLSDLQKEAE 1030 KLESEHPDQA 1040 QAILSRLAEI 1050 SDVWEEMKTT 1060 LKNREASLGE 1070 ASKLQQFLRD 1080 LDDFQSWLSR 1090 TQTAIASEDM 1100 PNTLTEAEKL 1110 LTQHENIKNE 1120 IDNYEEDYQK 1130 MRDMGEMVTQ 1140 GQTDAQYMFL 1150 RQRLQALDTG 1160 WNELHKMWEN 1170 RQNLLSQSHA 1180 YQQFLRDTKQ 1190 AEAFLNNQEY 1200 VLAHTEMPTT 1210 LEGAEAAIKK 1220 QEDFMTTMDA 1230 NEEKINAVVE 1240 TGRRLVSDGN 1250 INSDRIQEKV 1260 DSIDDRHRKN 1270 RETASELLMR 1280 LKDNRDLQKF 1290 LQDCQELSLW 1300 INEKMLTAQD 1310 MSYDEARNLH 1320 SKWLKHQAFM 1330 AELASNKEWL 1340 DKIEKEGMQL 1350 ISEKPETEAV 1360 VKEKLTGLHK 1370 MWEVLESTTQ 1380 TKAQRLFDAN 1390 KAELFTQSCA 1400 DLDKWLHGLE 1410 SQIQSDDYGK 1420 DLTSVNILLK 1430 KQQMLENQME 1440 VRKKEIEELQ 1450 SQAQALSQEG 1460 KSTDEVDSKR 1470 LTVQTKFMEL 1480 LEPLNERKHN 1490 LLASKEIHQF 1500 NRDVEDEILW 1510 VGERMPLATS 1520 TDHGHNLQTV 1530 QLLIKKNQTL 1540 QKEIQGHQPR 1550 IDDIFERSQN 1560 IVTDSSSLSA 1570 EAIRQRLADL 1580 KQLWGLLIEE 1590 TEKRHRRLEE 1600 AHRAQQYYFD 1610 AAEAEAWMSE 1620 QELYMMSEEK 1630 AKDEQSAVSM 1640 LKKHQILEQA 1650 VEDYAETVHQ 1660 LSKTSRALVA 1670 DSHPESERIS 1680 MRQSKVDKLY 1690 AGLKDLAEER 1700 RGKLDERHRL 1710 FQLNREVDDL 1720 EQWIAEREVV 1730 AGSHELGQDY 1740 EHVTMLQERF 1750 REFARDTGNI 1760 GQERVDTVNH 1770 LADELINSGH 1780 SDAATIAEWK 1790 DGLNEAWADL 1800 LELIDTRTQI 1810 LAASYELHKF 1820 YHDAKEIFGR 1830 IQDKHKKLPE 1840 ELGRDQNTVE 1850 TLQRMHTTFE 1860 HDIQALGTQV 1870 RQLQEDAARL 1880 QAAYAGDKAD 1890 DIQKRENEVL 1900 EAWKSLLDAC 1910 ESRRVRLVDT 1920 GDKFRFFSMV 1930 RDLMLWMEDV 1940 IRQIEAQEKP 1950 RDVSSVELLM 1960 NNHQGIKAEI 1970 DARNDSFTTC 1980 IELGKSLLAR 1990 KHYASEEIKE 2000 KLLQLTEKRK 2010 EMIDKWEDRW 2020 EWLRLILEVH 2030 QFSRDASVAE 2040 AWLLGQEPYL 2050 SSREIGQSVD 2060 EVEKLIKRHE 2070 AFEKSAATWD 2080 ERFSALERLT 2090 TLELLEVRRQ 2100 QEEEERKRRP 2110 PSPEPSTKVS 2120 EEAESQQQWD 2130 TSKGEQVSQN 2140 GLPAEQGSPR 2150 MAETVDTSEM 2160 VNGATEQRTS 2170 SKESSPIPSP 2180 TSDRKAKTAL 2190 PAQSAATLPA 2200 RTQETPSAQM 2210 EGFLNRKHEW 2220 EAHNKKASSR 2230 SWHNVYCVIN 2240 NQEMGFYKDA 2250 KTAASGIPYH 2260 SEVPVSLKEA 2270 VCEVALDYKK 2280 KKHVFKLRLN 2290 DGNEYLFQAK 2300 DDEEMNTWIQ 2310 AISSAISSDK 2320 HEVSASTQST 2330 PASSRAQTLP 2340 TSVVTITSES 2350 SPGKREKDKE 2360 KDKEKRFSLF GKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030673 axolemma
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0032437 cuticular plate
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0031430 M band
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0008091 spectrin
Cellular Component GO:0014731 spectrin-associated cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051693 actin filament capping
Biological Process GO:0007417 central nervous system development
Biological Process GO:0021556 central nervous system formation
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0071709 membrane assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:1903076 regulation of protein localization to plasma membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.