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Overview

Uniprot ID	Q01130
Protein Name	Serine/arginine-rich splicing factor 2
Gene Name	SRSF2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
36	TLRRVFEKYGRVGDV
52	IPRDRYTKESRGFAF

Function

Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment

Protein Sequence

10 MSYGRPPPDV 20 EGMTSLKVDN 30 LTYRTSPDTL 40 RRVFEKYGRV 50 GDVYIPRDRY 60 TKESRGFAFV 70 RFHDKRDAED 80 AMDAMDGAVL 90 DGRELRVQMA 100 RYGRPPDSHH 110 SRRGPPPRRY 120 GGGGYGRRSR 130 SPRRRRRSRS 140 RSRSRSRSRS 150 RSRYSRSKSR 160 SRTRSRSRST 170 SKSRSARRSK 180 SKSSSVSRSR 190 SRSRSRSRSR 200 SPPPVSKRES 210 KSRSRSKSPP 220 KSPEEEGAVS S

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
Biological Process	GO:0008380	RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.