Search Results
Overview
| Uniprot ID | Q01469 |
|---|---|
| Protein Name | Fatty acid-binding protein 5 |
| Gene Name | FABP5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 34 | GVGIALRKMGAMAKP |
| 55 | DGKNLTIKTESTLKT |
| 61 | IKTESTLKTTQFSCT |
| 72 | FSCTLGEKFEETTAD |
| 82 | ETTADGRKTQTVCNF |
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:21395585, PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0005324 | long-chain fatty acid transmembrane transporter activity |
| Molecular Function | GO:0001972 | retinoic acid binding |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:1990379 | lipid transport across blood-brain barrier |
| Biological Process | GO:0015909 | long-chain fatty acid transport |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway |
| Biological Process | GO:0031392 | regulation of prostaglandin biosynthetic process |
| Biological Process | GO:0099178 | regulation of retrograde trans-synaptic signaling by endocanabinoid |
| Biological Process | GO:0051930 | regulation of sensory perception of pain |
| Biological Process | GO:0098921 | retrograde trans-synaptic signaling by endocannabinoid |
| Biological Process | GO:0019433 | triglyceride catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[7] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.