Search Results

Overview

Uniprot IDQ01518
Protein NameAdenylyl cyclase-associated protein 1
Gene NameCAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
173 NRVLKEYKDVDKKHV
178 EYKDVDKKHVDWVKA
209 TTGLAWSKTGPVAKE
279 KHVSDDMKTHKNPAL
282 SDDMKTHKNPALKAQ
287 THKNPALKAQSGPVR
312 PQTSPSPKRATKKEP
317 SPKRATKKEPAVLEL
327 AVLELEGKKWRVENQ
328 VLELEGKKWRVENQE
364 VNTTLQIKGKINSIT
366 TTLQIKGKINSITVD
376 SITVDNCKKLGLVFD
404 VKVQVMGKVPTISIN
422 GCHAYLSKNSLDCEI
63 AEYLKISKEIGGDVQ
71 EIGGDVQKHAEMVHT
81 EMVHTGLKLERALLV

Function

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity

Protein Sequence

10 MADMQNLVER 20 LERAVGRLEA 30 VSHTSDMHRG 40 YADSPSKAGA 50 APYVQAFDSL 60 LAGPVAEYLK 70 ISKEIGGDVQ 80 KHAEMVHTGL 90 KLERALLVTA 100 SQCQQPAENK 110 LSDLLAPISE 120 QIKEVITFRE 130 KNRGSKLFNH 140 LSAVSESIQA 150 LGWVAMAPKP 160 GPYVKEMNDA 170 AMFYTNRVLK 180 EYKDVDKKHV 190 DWVKAYLSIW 200 TELQAYIKEF 210 HTTGLAWSKT 220 GPVAKELSGL 230 PSGPSAGSCP 240 PPPPPCPPPP 250 PVSTISCSYE 260 SASRSSLFAQ 270 INQGESITHA 280 LKHVSDDMKT 290 HKNPALKAQS 300 GPVRSGPKPF 310 SAPKPQTSPS 320 PKRATKKEPA 330 VLELEGKKWR 340 VENQENVSNL 350 VIEDTELKQV 360 AYIYKCVNTT 370 LQIKGKINSI 380 TVDNCKKLGL 390 VFDDVVGIVE 400 IINSKDVKVQ 410 VMGKVPTISI 420 NKTDGCHAYL 430 SKNSLDCEIV 440 SAKSSEMNVL 450 IPTEGGDFNE 460 FPVPEQFKTL 470 WNGQKLVTTV TEIAG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0098793 presynapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0008179 adenylate cyclase binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0098885 modification of postsynaptic actin cytoskeleton
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.