Search Results
Overview
| Uniprot ID | Q01581 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
| Gene Name | HMGCS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | CYSVYCKKIHAQWQK |
| 273 | PYCKLVQKSLARMLL |
| 330 | SSELFSQKTKASLLV |
| 498 | EHIPSPAKKVPRLPA |
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis
Protein Sequence
10
MPGSLPLNAE
20
ACWPKDVGIV
30
ALEIYFPSQY
40
VDQAELEKYD
50
GVDAGKYTIG
60
LGQAKMGFCT
70
DREDINSLCM
80
TVVQNLMERN
90
NLSYDCIGRL
100
EVGTETIIDK
110
SKSVKTNLMQ
120
LFEESGNTDI
130
EGIDTTNACY
140
GGTAAVFNAV
150
NWIESSSWDG
160
RYALVVAGDI
170
AVYATGNARP
180
TGGVGAVALL
190
IGPNAPLIFE
200
RGLRGTHMQH
210
AYDFYKPDML
220
SEYPIVDGKL
230
SIQCYLSALD
240
RCYSVYCKKI
250
HAQWQKEGND
260
KDFTLNDFGF
270
MIFHSPYCKL
280
VQKSLARMLL
290
NDFLNDQNRD
300
KNSIYSGLEA
310
FGDVKLEDTY
320
FDRDVEKAFM
330
KASSELFSQK
340
TKASLLVSNQ
350
NGNMYTSSVY
360
GSLASVLAQY
370
SPQQLAGKRI
380
GVFSYGSGLA
390
ATLYSLKVTQ
400
DATPGSALDK
410
ITASLCDLKS
420
RLDSRTGVAP
430
DVFAENMKLR
440
EDTHHLVNYI
450
PQGSIDSLFE
460
GTWYLVRVDE
470
KHRRTYARRP
480
TPNDDTLDEG
490
VGLVHSNIAT
500
EHIPSPAKKV
510
PRLPATAAEP
520
EAAVISNGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.